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TranscriptomicsGene expression profile of DAP12 knockdown THP-1 cells following exposure to phorbol 12-myristate 13-acetate
Nasu-Hakola disease (NHD), also designated polycystic lipomembranous osteodysplasia with sclerosing leukoencephalopathy (PLOSL), is a rare autosomal recessive disorder characterized by progressive presenile dementia and formation of multifocal bone cysts, caused by a loss-of-function mutation of DAP...
ORGANISM(S): Homo sapiens 
2011-11-17 | E-GEOD-33503 | biostudies-arrayexpress
TranscriptomicsNon-phosphorylated FTY720 induces apoptosis of human microglia by activating SREBP2
A synthetic analog of sphingosine named FTY720 (Fingolimod), phosphorylated by sphingosine kinase-2, interacts with sphingosine-1-phosphate (S1P) receptors expressed on various cells. FTY720 suppresses the disease activity of multiple sclerosis (MS) chiefly by inhibiting S1P-dependent egress of auto...
ORGANISM(S): Homo sapiens 
2011-04-16 | E-GEOD-28642 | biostudies-arrayexpress
TranscriptomicsGene expression profile of THP-1 monocytes following knockdown of DAP12, a causative gene for Nasu-Hakola disease
Nasu-Hakola disease (NHD), also designated polycystic lipomembranous osteodysplasia with sclerosing leukoencephalopathy (PLOSL), is a rare autosomal recessive disorder characterized by progressive presenile dementia and formation of multifocal bone cysts, caused by a loss-of-function mutation of DAP...
ORGANISM(S): Homo sapiens 
2011-11-17 | E-GEOD-33500 | biostudies-arrayexpress
TranscriptomicsGene expression profile of U373MG exposed to novel anti-cancer 1,2,3,4-tetrahydroisoquinoline alkaloids
Background: Glioblastoma is the most aggressive form of brain tumors showing resistance to treatment with various chemotherapeutic agents. The most effective way to eradicate glioblastoma requires the concurrent inhibition of multiple signaling pathways and target molecules involved in the progressi...
ORGANISM(S): Homo sapiens 
2012-05-19 | E-GEOD-36619 | biostudies-arrayexpress
TranscriptomicsGene expression of ultra violet irradiation of silk worm Bombyx mori larvae
3 day of fifth instar larvae were treated with ultra-violet (UV) rays using UVL-56 (1350?W/cm2, UVP) for 6 and 12 hours (29.2 and 58.32 J/cm2). Since, larvae of each group rare on artificial diet for 24 hour and dissected fatbody. We examined gene expression profile in these groups. Gene expression ...
ORGANISM(S): Bombyx mori 
2015-02-26 | E-GEOD-55816 | biostudies-arrayexpress
TranscriptomicsGene expression of abnormal uric acid synthesis animal model of silk worm Bombyx mori.
Uric acid (UA) is the final product of purine metabolism and plays an important role as a physiological antioxidant. In recent years, several different groups have reported a correlation between decreased UA in Parkinson’s disease (PD) and clinical progression and stage of PD. However, little is kno...
ORGANISM(S): Bombyx mori 
2013-07-24 | E-GEOD-37735 | biostudies-arrayexpress
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