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TranscriptomicsEffects of HMGN variants on cellular transcription profile
HMGN (high mobility group N) is a family of intrinsically disordered nuclear proteins that binds to nucleosomes, alters the structure of chromatin and affects transcription. A major unresolved question is the extent of functional specificity, or redundancy, between the various members of the HMGN p...
ORGANISM(S): Mus musculus 
2011-02-28 | E-GEOD-27546 | biostudies-arrayexpress
TranscriptomicsGlobal Gene Expression Analysis of Murine Limb Development
Detailed information about stage-specific changes in gene expression is crucial for understanding the gene regulatory networks underlying development and the various signal transduction pathways contributing to morphogenesis. Here, we describe the global gene expression dynamics during early murine ...
ORGANISM(S): Mus musculus 
2011-12-31 | E-GEOD-30138 | biostudies-arrayexpress
TranscriptomicsSost and its paralog Sostdc1 coordinate digit number in a Gli3-dependent manner
WNT signaling is critical in most aspects of skeletal development and homeostasis, and antagonists of WNT signaling are emergning as key regulatory proteins with great promise as therapeutic agents for bone disorders. Until recently Sost and its paralog Sostdc1 have been described as growth factors ...
ORGANISM(S): Mus musculus 
2013-08-17 | E-GEOD-44325 | biostudies-arrayexpress
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