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MetabolomicsCharacterization of active peptides derived from three leeches and comparison of their anti-thrombotic mechanisms using the tail vein thrombosis model in mice and metabonomics

BACKGROUND AND AIMS: The increasing incidence of cardiovascular diseases has created an urgent need for safe and effective anti-thrombotic agents. Leech, as a traditional Chinese medicine, has the effect of promoting blood circulation and removing blood stasis, but its real mater...

2024-01-18 | MTBLS9306 | MetaboLights
TranscriptomicsmRNA Poly(A)-tail Changes Specified by Deadenylation Broadly Reshape Translation in Drosophila Oocytes and Early Embryos
Because maturing oocytes and early embryos lack transcription, posttranscriptional regulatory processes must control their development. To better understand this control, we profiled translational efficiencies and poly(A)-tail lengths throughout Drosophila oocyte maturation and early embryonic deve...
ORGANISM(S): Drosophila melanogaster 
2016-08-08 | E-GEOD-83616 | biostudies-arrayexpress
TranscriptomicsPoly(A)-tail profiling reveals an embryonic switch in translational control
Poly(A) tails enhance the stability and translation of most eukaryotic messenger RNAs, but difficulties in globally measuring poly(A)-tail lengths have impeded greater understanding of poly(A)-tail function. Here we describe poly(A)-tail length profiling by sequencing (PAL-seq) and apply it to measu...
ORGANISM(S): Arabidopsis thaliana 
2014-01-29 | E-GEOD-52809 | biostudies-arrayexpress
TranscriptomicsBehavioural and brain gene expression profiling in pigs during tail biting outbreaks - evidence of a tail biting resistant phenotype
Brain gene expression in pigs housed in a pen during a tail biting outbreak compared with pigs housed in control pens.
ORGANISM(S): Sus scrofa 
2012-09-30 | E-MEXP-3643 | biostudies-arrayexpress
GenomicsThe N-terminal Tail of CENP-A Confers Epigenetic Stability to Centromeres via the CENP-T Branch of the CCAN in Fission Yeast
We employ the well-studied fission yeast centromere to investigate the function of the CENP-A (Cnp1) N-tail. We show that alteration of the N-tail did not affect Cnp1 loading at centromeres, outer kinetochore formation, or spindle checkpoint signaling, but nevertheless elevated chromosome loss. N-Ta...
ORGANISM(S): Schizosaccharomyces pombe 
2015-04-16 | E-GEOD-63350 | biostudies-arrayexpress
TranscriptomicsBrain gene expression differences are associated with abnormal tail biting behavior in pigs
Gene expression in the hypothalamus and pre frontal cortex in pigs performing and receiving tail biting behaviour was compared with expression in pigs not performing or receiving tail biting
ORGANISM(S): Sus scrofa 
2013-11-12 | E-MEXP-3630 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mouse B cells expressing anti-HEL IgM BCR and IgMG BCR to investigate the effect of IgG cytoplasmic tail on BCR-respose genes
IgG cytoplasmic tail interferes with the induction of antigen-response genes Experiment Overall Design: Comparing antigen-induced genes between B cells expressing anti-HEL IgM BCR and IgMG BCR (chimeric receptor where the extracellular spacer, transmembrane, and cytoplasmic domain of IgM are replace...
ORGANISM(S): Mus musculus 
2008-06-15 | E-GEOD-7218 | biostudies-arrayexpress
TranscriptomicsRNA sequencing of native and ex vivo cultured murine tail tendon fascicles
Tendon fascicles were analysed directly after isolation from the tail of freshly euthanized mice and after of after ex vivo culture for 6 days. Fascicles were cultured in either serum containing medium (10%) or in serum-free medium at 21% oxygen and 37 degrees celsius.
ORGANISM(S): Mus musculus 
2020-09-15 | E-MTAB-9540 | biostudies-arrayexpress
TranscriptomicsPoly(A) tail length profiling of mRNAs from fission yeast
To obtain global data on polyadenylation of mRNAs, we fractionated the mRNAs according to their poly(A) tail length using a poly-U sepharose column followed by differential elution at five temperatures. Five mRNA fractions with distinct ranges of poly(A) tail length were then hybridized to microarr...
ORGANISM(S): Schizosaccharomyces pombe 
2007-05-16 | E-TABM-217 | biostudies-arrayexpress
TranscriptomicsHistone H4 N-terminal tail mutants
A series of yeast carrying K->R mutations in the histone H4 N-terminal tail were profiled by gene expression array in mid-log phase.
ORGANISM(S): Saccharomyces cerevisiae 
2010-06-10 | E-GEOD-2324 | biostudies-arrayexpress
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