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ProteomicsProteasome dysfunction leads to enhanced autophagy mediated degradation of mutant lamin A/C
Lamin A/C are nuclear intermediate filament proteins that form a proteinaceous meshwork called lamina beneath the inner nuclear membrane. Mutations in the LMNA gene encoding lamin A/C cause a heterogenous group of inherited degenerative diseases known as laminopathies. Previous studies have revealed...
ORGANISM(S): Homo sapiens (Human) 
2022-09-07 | PXD033937 | Pride
Lamin a/c Autophagy Ubiquitin-proteasome-system Disease mutations Degradation Ubiquitin 
ProteomicsAnalysis of extracellular matrix proteins from 3D cultures of primary prostate fibroblasts, DU145 cells and mixed cells
Composition and organization of extracellular matrix (ECM) in tumor stroma are important regulators of cancer cell behavior. Therefore, ECM produced by cancer associated fibroblasts is often used in in vitro experiments. Here, a proteome wide analysis of ECM proteins in 3D culture is analysed.
ORGANISM(S): Homo sapiens (Human) 
2018-03-13 | PXD006563 | Pride
3d culture Prostate cancer Fibroblast Extracellular matrix 
ProteomicsComparison of extracellular matrix in prostate tissue samples and in cultures of primary fibroblasts from prostate cancer patients
xtracellular matrix from prostate tissue samples and from cultures of primary fibroblasts of the same samples from individuals was analysed by mass spectrometry.
ORGANISM(S): Homo sapiens (Human) 
2018-03-13 | PXD006562 | Pride
Prostate tissue Extracellular matrix Primary fibroblasts 
TranscriptomicsInvestigation of endothelial cell gene dysregulation in early pulmonary arterial hypertension disease model
Endothelial cell (EC) dysfunction plays a key role in the pathogenesis of pulmonary arterial hypertension (PAH). To avoid cell cultures and whole lung tissue samples, we have, for the first time, used CD31 antibody coated magnetic beads in conjunction with genome scale RNA expression microarrays to ...
ORGANISM(S): Rattus norvegicus 
2014-02-06 | E-GEOD-42767 | biostudies-arrayexpress
TranscriptomicsDeleterious assembly of the lamin A/C mutant p.S143P causes ER stress in familial dilated cardiomyopathy
Mutation of the LMNA gene, encoding nuclear lamin A and lamin C (hereafter lamin A/C), is a common cause of familial dilated cardiomyopathy (DCM). Among Finnish DCM patients, the founder mutation c.427T>C (p.S143P) is the most frequently reported genetic variant. Here, we show that p.S143P lamin A/C...
ORGANISM(S): Homo sapiens 
2016-06-10 | E-GEOD-82290 | biostudies-arrayexpress
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