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GenomicsUbiquitin-Proteasome System Dysregulation in Alzheimer's Disease Impacts Protein Abundance
Ubiquitin-Proteasome System Dysregulation in Alzheimer's Disease Impacts Protein Abundance
PRJNA1449257 | ENA
UnknownActivation of the ubiquitin-proteasome system contributes to oculopharyngeal muscular dystrophy through muscle atrophy.
Not available
S-EPMC8791501 | biostudies-literature
ModelsProctor2007 - Age related decline of proteolysis, ubiquitin-proteome system
Proctor2007 - Age related decline of proteolysis, ubiquitin-proteome system This is a stochastic model of the ubiquitin-proteasome system for a generic pool of native proteins (NatP), which have a half-life of about 10 hours under normal conditions. It is assumed that these ...
2024-09-02 | BIOMD0000000105 | BioModels
TranscriptomicsTranscription profiling of rat liver and adipose tissues after 24 h-fasting
The functional balance between brown adipose tissue (BAT) and white adipose tissue (WAT) is important for metabolic homeostasis. We compared the effects of fasting on the gene expression profiles in BAT, WAT and liver, using DNA microarray analysis. Tissues were obtained from rats that had been fe...
ORGANISM(S): Rattus norvegicus 
2008-06-15 | E-GEOD-7623 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human glioblastoma cell lines after treatment with two ubiquitin-proteasome system inhibitors to characterize the molecular signals of cell death by necrosis
The regulation of necrotic death and its relevance in anti-cancer therapy are largely unknown. Here we have investigated the pro-apoptotic and pro-necrotic activities of two ubiquitin-proteasome system inhibitors (UPSIs): bortezomib and G5. The present study points out that the glioblastoma cell lin...
ORGANISM(S): Homo sapiens 
2009-10-16 | E-GEOD-14889 | biostudies-arrayexpress
TranscriptomicsUbiquitin-Proteasome System Dysregulation in Alzheimer's Disease Impacts Protein Abundance
Alzheimer's disease (AD) is a relentlessly progressive, fatal neurodegenerative disorder that results in widespread protein dysfunctions. However, the full extent of aberrant proteomic changes in AD and their impact on cellular physiology remains unknown. This is, in part, because of the challenges ...
ORGANISM(S): Homo sapiens 
2026-05-04 | GSE327021 | GEO
UnknownPoxvirus exploitation of the ubiquitin-proteasome system.
Not available
S-EPMC3185573 | biostudies-literature
ProteomicsNovel functions of the ubiquitin-independent proteasome system in regulating Xenopus germline development
In most species, early germline development occurs in the absence of transcription with germline determinants subject to complex translational and post-translational regulations. Here, we report for the first time that early germline development is influenced by dynamic regulation of the proteasome ...
ORGANISM(S): Xenopus laevis (African clawed frog) 
2019-04-10 | PXD013446 | Pride
Germline development Dnd1 Xenopus Oocyte-to-embryo transition Ubiquitin-independent proteasome 
TranscriptomicsThe FoxO signature in protein breakdown
Under stress conditions mammalian cells activate compensatory mechanisms to survive and maintain cellular function. During catabolic conditions, such as low nutrients, systemic inflammation, cancer or infections, protein breakdown is enhanced and aminoacids are released from muscles to sustain liver...
ORGANISM(S): Mus musculus 
2015-04-24 | E-GEOD-52667 | biostudies-arrayexpress
ProteomicsDual roles of mTORC1-dependent activation of the ubiquitin-proteasome system in muscle proteostasis
Muscle size is controlled by the PI3K-PKB/Akt-mTORC1-FoxO pathway, which integrates signals from growth factors, energy and amino acids to activate protein synthesis and inhibit protein breakdown. While mTORC1 activity is necessary for PKB/Akt-induced muscle hypertrophy, its constant activation alon...
ORGANISM(S): Mus musculus (Mouse) 
2022-10-28 | PXD034117 | Pride
Tmt Lc-ms Mtor Muscle 
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