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TranscriptomicsIdentification of genes that are regulated by TAK1 in human cutaneous T cell lymphoma HuT-102 cells
We previously reported that human T cell lymphotropic virus 1 (HTLV-1) Tax oncoprotein constitutively activates TAK1. Here, we established Tax-positive HuT-102 cells stably downregulated TAK1 expression by short-hairpin RNA (HuT-shTAK1 cells), and investigated the physiological function of TAK1. Mic...
ORGANISM(S): Homo sapiens 
2009-08-18 | E-GEOD-16219 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mouse testicular Sertoli TTE3 cells with SV40 large T antigent to investigate denes in nonpermissive temperature-induced cell differentiation of testicular Sertoli TTE3 cells
We performed global scale microarray analysis to identify detailed mechanisms by which nonpermissive temperature induces cell differentiation in testicular Sertoli TTE3 cells harboring temperature-sensitive SV40 large T-antigen by using an Affymetrix GeneChip system. Testicular Sertoli TTE3 cells us...
ORGANISM(S): Mus musculus 
2008-06-15 | E-GEOD-6961 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of rat astrocyte cell line RCG-12 to investigate cell growth arrest and differentiation
We performed global scale microarray analysis to identify detailed mechanisms by which nonpermissive temperature induces cell growth arrest and differentiation in astrocyte RCG-12 cells harboring temperature-sensitive simian virus 40 large T-antigen by using an Affymetrix GeneChip system. Astrocyte ...
ORGANISM(S): Rattus norvegicus 
2008-06-15 | E-GEOD-7501 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of apoptosis induced by heat stress in U937 human lymphoma cells
Hyperthermia is widely used to treat patients with various cancers. 42.5˚C is well known as the inflection point of hyperthermia and generally up to 42˚C of hyperthermia is used in clinical cases combined with other therapies. Here, the effects of heat stress at 42 or 44˚C for 15 min on the gene exp...
ORGANISM(S): Homo sapiens 
2010-08-11 | E-GEOD-23405 | biostudies-arrayexpress
TranscriptomicsIdentification of genes that regulated by IRF4 in human cutaneous T cell lymphoma HuT-102 cells
The microarray analysis showed an interesting up-regulation in the set of genes controlling the development of Th1, mainly IFN-gamma, and other type 1 interferon response genes including CXCL10 in IRF4 knocked-down HuT-102 cells. HuT-102 cells, a human cutaneous T cell lymphoma, were transiently tra...
ORGANISM(S): Homo sapiens 
2010-06-08 | E-GEOD-22036 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human U937 lymphoma cells treated with paeony root (Paeoniae radix) (time series)
Paeoniflorin (PF) isolated from paeony root (Paeoniae radix) has been used as an herbal medicine in East Asis for its anti-allergic, anti-inflammatory, and immunoregulatory effects. PF is known to be a chemical heat shock protein (HSP) inducer. The effects on the gene expression in human lymphoma U9...
ORGANISM(S): Homo sapiens 
2008-06-16 | E-GEOD-8228 | biostudies-arrayexpress
TranscriptomicsTelmisartan Improves Insulin Resistance with Modulating Adipose Tissue Macrophage Polarization in High Fat-fed Mice
Diet-induced obesity is reported to induce a phenotypic switch in adipose tissue macrophages from an antiinflammatory M2 state to a proinflammatory M1 state. Telmisartan, an angiotensin II type 1 receptor antagonist and a peroxisome proliferator-activated receptor-gamma (PPAR-gamma) agonist, repor...
ORGANISM(S): Mus musculus 
2010-01-22 | E-GEOD-19954 | biostudies-arrayexpress
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