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TranscriptomicsMaternal peripheral blood natural killer cells incorporate placenta-associated microRNAs during pregnancy
Although recent studies have revealed that microRNAs (miRNAs) regulate fundamental Natural Killer (NK) cell processes including cytotoxicity and cytokine production, little is known about the miRNA-gene regulatory relationships in maternal peripheral blood NK (pNK) cells during pregnancy. To predict...
ORGANISM(S): Homo sapiens 
2015-01-13 | E-GEOD-64884 | biostudies-arrayexpress
TranscriptomicsHuman exosomal placenta-specific miRNAs modulate expression of target genes in maternal immune cells during pregnancy
We investigated placenta-specific miRNA miR-517a (miR-517a-3p) functions in Jurkat cells. For this purpose, we identified candidate target mRNAs of the placenta-specific miRNAs using DNA microarray analysis. Transfection of Jurkat cells with miR-517a significantly downregulated 123 genes. Among the ...
ORGANISM(S): Homo sapiens 
2013-09-13 | E-GEOD-50814 | biostudies-arrayexpress
TranscriptomicsMiR-376c down-regulation accelerates EGF-dependent migration by targeting GRB2 in the HuCCT1 human intrahepatic cholangiocarcinoma cell line
The biological significance of the down-regulation of miR-376c in HuCCT1 cells is unknown. We revealed that miR-376c significantly reduced EGF-dependent cell migration through its target GRB2 in HuCCT1 cells. To elucidate key molecules in EGF-dependent HuCCT1 migration, in which GRB2 upregulation is...
ORGANISM(S): Homo sapiens 
2013-05-23 | E-GEOD-47186 | biostudies-arrayexpress
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