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MetabolomicsMetabolomic Profiling Reveals Key Metabolic Alterations in MCF7 Tamoxifen-Resistant Cells Following EPAS1 Inhibition

This study aims to investigate the metabolic alterations associated with acquired tamoxifen (TAM) resistance in luminal A breast cancer cells. Using untargeted LC-MS/MS metabolomics, we compared parental MCF7 and TAM-resistant MCF7/Tam1 cells to identify key metabolic pathways affected by EPAS1 (...

2025-07-04 | MTBLS12677 | MetaboLights
GenomicsIntegrative Analyses of Gene Expression and DNA Methylation Profiles in a Breast Cancer Cell Line Model of Tamoxifen-Resistance Indicate a Crucial Role of Cells with Stem-like Properties
Purpose: Development of resistance to tamoxifen is an important clinical issue in the treatment of patients with breast cancer. Tamoxifen resistance may be the result of the acquisition of epigenetic regulation such as DNA methylation within breast cancer cells resulting in changed mRNA expression o...
ORGANISM(S): Homo sapiens 
2014-02-03 | E-GEOD-40665 | biostudies-arrayexpress
TranscriptomicsGenotoxic, epigenetic, and transcriptomic effects of tamoxifen in mouse liver
Tamoxifen is a non-steroidal anti-estrogenic drug widely used for the treatment and prevention of breast cancer in women; however, there is evidence that tamoxifen is hepatocarcinogenic in rats, but not in mice. Additionally, it has been reported that tamoxifen may cause non-alcoholic fatty liver di...
ORGANISM(S): Mus musculus 
2014-10-11 | E-GEOD-62267 | biostudies-arrayexpress
TranscriptomicsTamoxifen-resistant human breast cancer cell lines
A functional genetic screen to identify genes causing tamoxifen resistance in an estrogen-dependent human breast cancer cell model was performed. By insertion of defective retrovirus into the genome, individual genetic changes were introduced at random in ZR-75-1 cells. Subsequently, infected cells ...
ORGANISM(S): Homo sapiens 
2009-12-09 | E-GEOD-14513 | biostudies-arrayexpress
TranscriptomicsChromosome 11q and its association with CCND1 gene amplification and tamoxifen resistance in premenopausal breast cancer
Background: The amplification event occurring at chromosome locus 11q13, reported in several different cancers, includes a number of potential oncogenes. We have previously reported amplification of one such oncogene, CCND1, to be correlated with an adverse effect of tamoxifen in premenopausal breas...
ORGANISM(S): Homo sapiens 
2008-10-07 | E-GEOD-12759 | biostudies-arrayexpress
TranscriptomicsCXCR4 activation maintains a stem cell population in tamoxifen-resistant breast cancer cells through AHR signaling
Targeting the estrogen signaling pathway has proved to be of great value in the treatment of human breast cancer. Tamoxifen, a selective estrogen receptor modulator (SERM), is the most widely used antiestrogen. However, only 40-50% of patients with estrogen receptor (ER) positive breast cancer benef...
ORGANISM(S): Homo sapiens 
2012-12-21 | E-GEOD-31831 | biostudies-arrayexpress
TranscriptomicsGene expression profiling of invasive breast cancer events from the tamoxifen prevention trial
Gene expression profiling of invasive breast cancer events from the tamoxifen prevention trial validates low estrogen receptor mRNA level as the main determinant of tamoxifen resistance in estrogen receptor positive breast cancer. In NSABP Breast Cancer Prevention Trial (BCPT), tamoxifen reduced th...
ORGANISM(S): Homo sapiens 
2011-12-08 | E-GEOD-12665 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human tamoxifen-resistant MCF-7 wild-type murine xenograft tumors with E2-supplemented tumors MCF7 xenografts
In order to help determine the genes involved in resistance of breast cancer to endocrine therapy, we compared global gene expression profiles of tamoxifen-resistant MCF-7 WT xenograft tumors with E2-supplemented tumors. Experiment Overall Design: MCF7 xenografts were established in ovariectomized f...
ORGANISM(S): Homo sapiens 
2008-04-09 | E-GEOD-7327 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human MCF-7 breast cancer cell line transfected with adenovirus expressing Erbeta treated with estrogen or tamoxifen reveals tamoxifen can selectively regulate a unique set of >60 genes, which are minimally regulated by estradiol (E2) or raloxifene.
The beneficial effect of the selective estrogen receptor (ER) modulator tamoxifen in the treatment and prevention of breast cancer is assumed to be through its ability to antagonize the stimulatory actions of estrogen, although tamoxifen can also have some estrogen-like agonist effects. Here, we rep...
ORGANISM(S): Homo sapiens 
2007-10-02 | E-GEOD-4025 | biostudies-arrayexpress
TranscriptomicsEndocrine response in invasive lobular carcinoma is characterized by unique estrogen-mediated gene expression and de novo tamoxifen resistance (MM134)
Invasive lobular carcinoma (ILC) is a histological subtype of breast cancer that is frequently associated with favorable outcomes, as ~90% of ILC express the estrogen receptor (ER). However, recent retrospective analyses suggest that ILC patients receiving adjuvant endocrine therapy may not benefit ...
ORGANISM(S): Homo sapiens 
2014-01-16 | E-GEOD-50693 | biostudies-arrayexpress
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