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ModelsTan2012 - Antibiotic Treatment, Inoculum Effect
Tan2012 - Antibiotic Treatment, Inoculum Effect The efficacy of many antibiotics decreases with increasing bacterial density, a phenomenon called the ‘inoculum effect’ (IE). This study reveals that, for ribosome-targeting antibiotics, IE is due to bistable inhibition of bacterial g...
2024-09-02 | BIOMD0000000425 | BioModels
ProteomicsHolistic engineering of cell-free systems through proteome-reprogramming synthetic circuits
Synthetic biology has focused on engineering genetic modules that operate orthogonally from the host cells. A synthetic circuit, however, can be designed to reprogram the host proteome, which in turn enhances the function of the synthetic circuit. Here, we apply this holistic synthetic biology conce...
ORGANISM(S): Escherichia coli 
2020-05-14 | PXD018858 | Pride
Synthetic biology Proteome Cell-free protein synthesis Orthogonality 
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