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TranscriptomicsGene expression profiling and ChIP-Seq study of HoxB4-mediated HSC development from ES cells
This SuperSeries is composed of the following subset Series: GSE33953: Time-course transcriptome measure of HoxB4-mediated HSC development from ES cells GSE34013: Time-course HoxB4 ChIP-Seq during HSC development from ES cells Refer to individual Series
ORGANISM(S): Mus musculus 
2012-03-23 | E-GEOD-34014 | biostudies-arrayexpress
TranscriptomicsTime-course transcriptome measure of HoxB4-mediated HSC development from ES cells
Efficient in vitro generation of hematopoietic stem cells (HSCs) from embryonic stem cells (ESCs) holds great promise for cell-based therapies of hematological diseases. To date, HoxB4 remains to be the most effective transcription factor (TF) whose over-expression in ESCs confers long-term repopula...
ORGANISM(S): Mus musculus 
2012-03-23 | E-GEOD-33953 | biostudies-arrayexpress
GenomicsTime-course HoxB4 ChIP-Seq during HSC development from ES cells
Efficient in vitro generation of hematopoietic stem cells (HSCs) from embryonic stem cells (ESCs) holds great promise for cell-based therapies of hematological diseases. To date, HoxB4 remains to be the most effective transcription factor (TF) whose over-expression in ESCs confers long-term repopula...
ORGANISM(S): Mus musculus 
2012-03-23 | E-GEOD-34013 | biostudies-arrayexpress
GenomicsGenome-wide comparison of DNA hydroxymethylation in mouse embryonic stem cells and neural progenitor cells by relative quantitative hMeDIP-seq
DNA hydroxymethylation (5hmC) represents a new layer of epigenetic regulation in addition to DNA methylation (5mC). The genome-wide patterns of 5hmC distribution in many tissues and cells have recently been revealed by hydroxymethylated DNA immunoprecipitation (hMeDIP) followed by high throughput se...
ORGANISM(S): Mus musculus 
2013-03-08 | E-GEOD-40810 | biostudies-arrayexpress
TranscriptomicsGenome-wide Regulation of 5hmC, 5mC and Gene Expression by Tet1 Hydroxylase in Mouse Embryonic Stem Cells (ChIP-seq data)
DNA methylation of C5-cytosine (5mC) in the mammalian genome is a key epigenetic event that is critical for various cellular processes. However, how the genome-wide 5mC pattern is dynamically regulated remains a fundamental question in epigenetic biology. The TET family of 5mC hydroxylases, which co...
ORGANISM(S): Mus musculus 
2011-04-21 | E-GEOD-28532 | biostudies-arrayexpress
TranscriptomicsLong Non-coding RNA expression profiles in Hereditary Haemorrhagic Telangiectasia
Hereditary Haemorrhagic Telangiectasia (HHT) is an autosomal dominantly inherited vascular disease characterized by the presence of mucocutaneous telangiectasia and arteriovenous malformations in visceral organs. HHT is predominantly caused by mutations in ENG and ACVRL1, Which both belong to the TG...
ORGANISM(S): Homo sapiens 
2014-12-19 | E-GEOD-53515 | biostudies-arrayexpress
TranscriptomicsThe transcriptome-wide CPSF6-induced APA alterations in HCC cells
In this study, we showed that CPSF6 promoted HCC cell growth, migration and metastasis in vitro and in vivo. In order to understand the underlying mechanisms of CPSF6, we aimed to perform a APA profiling analysis in hepatocyte and hepatoma carcinoma cells under different CPSF6 expression conditions ...
ORGANISM(S): Homo sapiens 
2021-04-01 | E-MTAB-9458 | biostudies-arrayexpress
GenomicsCK2 regulates transcriptional elongation
CK2 binds to actively transcribed regions in the genome and regulates transcriptional elongation. Identification of genome-wide binding sites of CK2?, and examination of the effect of Pol II binding upon CK2 inhibition in LNCaP cells
ORGANISM(S): Homo sapiens 
2014-09-30 | E-GEOD-58607 | biostudies-arrayexpress
UnknownA comprehensive iterative approach is highly effective in diagnosing individuals who are exome negative.
Not available
S-EPMC6295275 | biostudies-literature
UnknownA toolkit for genetics providers in follow-up of patients with non-diagnostic exome sequencing.
Not available
S-EPMC7385984 | biostudies-literature
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