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ProteomicsIntegrated proteome and malonylome analyses reveal the potential meaning of TLN1 and ACTB in end-stage renal disease
Purpose: End-stage renal disease (ESRD) is a condition that is characterized by the loss of kidney function. ESRD patients suffer from various endothelial dysfunctions, inflammation, and immune system defects. Lysine malonylation (Kmal) is a recently discovered post-translational modification (PTM)....
ORGANISM(S): Homo sapiens (Human) 
2023-10-24 | PXD035147 | Pride
Lysine malonylation (kmal) Platelet activation Post-translational modification (ptm) End-stage renal disease (esrd) Chronic kidney disease (ckd) 
UnknownSchizonepeta tenuifolia Briq-Saposhnikovia divaricata decoction alleviates atopic dermatitis via downregulating macrophage TRPV1.
Not available
S-EPMC11383762 | biostudies-literature
ProteomicsRPL6 interacts with HMGCS1 to stabilize HIF-1α by promoting cholesterol production in hepatocellular carcinoma.
The identification of predictive markers to determine the premetastatic phase before metastasis is critical for developing effective strategies for early detection and prevention. By applying the dynamic network biomarker (DNB) approach to analyze time-series transcriptomic data from a pulmonary met...
ORGANISM(S): Homo sapiens (Human) 
2025-10-20 | PXD064850 | Pride
Hepatocellular carcinoma  metastasis  rpl6  hmgcs1  cholesterol 
ProteomicsRPL6 interacts with HMGCS1 to stabilize HIF-1α by activating cholesterol biosynthesis in hepatocellular carcinoma.
The identification of predictive markers to determine the premetastatic phase before metastasis is critical for developing effective strategies for early detection and prevention. By applying the dynamic network biomarker (DNB) approach to analyze time-series transcriptomic data from a pulmonary met...
ORGANISM(S): Homo sapiens (Human) 
2025-10-20 | PXD054740 | Pride
Hepatocellular carcinoma  metastasis  rpl6  hmgcs1  cholesterol 
ProteomicsMouse cortex immunoprecipitation-mass spectrometry
To determine the mechanism for how Kctd10 deficiency impacts brain development, co-immunoprecipitation (co-IP) was performed to identify KCTD10-interacting proteins from the E14.5 cerebral cortex using a KCTD10 antibody, followed by mass spectrometric analysis. In total, 143 proteins uniquely precip...
ORGANISM(S): Mus musculus (Mouse) 
2024-05-22 | PXD050135 | Pride
E14.5 Mouse Kctd10 Crebral cortex 
Proteomics4DLabelfree quantitative acetylation of modified proteome in Toxoplasma gondii protein fluid samples
A series of advanced techniques such as protein extraction, enzyme digestion, enrichment of modified peptide, tandem analysis of liquid chromatography-mass spectrometry and bioinformation analysis were used to study the modified quantitative omics of the samples.
ORGANISM(S): Toxoplasma gondii GT1 
2026-09-14 | PXD052656 | Pride
Toxoplasma acetylation 
UnknownYiaC and CobB regulate lysine lactylation in Escherichia coli.
Not available
S-EPMC9636275 | biostudies-literature
ProteomicsActivation of Wnt/β-catenin signaling in subchondral bone osteoblast responced to hypoxia lead to osteoarthritis-like phenotype in articular chondrocyte
The crosstalk between the cartilage and subchondral bone plays a crucial role in the pathogenesis and progression of OA. The aim of this study was to identify soluble mediators released by osteoblasts that could induce the release of catabolic factors by chondrocytes. Global protein sequencing of su...
ORGANISM(S): Homo sapiens (Human) 
2025-05-06 | PXD021135 | Pride
Osteoarthritis(oa)  subchondral bone  articular cartilage  procoagulation  hypoixa  wnt pathway  β-catenin 
ProteomicsKu80 lysine crotonylation conversion to SUMOylation facilitates DNA non-homologous end joining and cellular resistance to radiation
A DNA double-strand break (DSB) is the most serious DNA damage and is also the principal molecular basis of radiotherapy. Upon DNA damage, the Ku80 is recruited and forms a critical DNA-PK complex at the DSB sites with Ku70 and the catalytic subunit (DNA-PKcs) to initiate DNA repair. How DNA-PK is a...
ORGANISM(S): Homo sapiens (Human) 
2025-05-07 | PXD061039 | Pride
Dna double-strand break repair  ku80  crotonylation  sumoylation  dna-pk holoenzyme assembly  radioresistance 
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