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ProteomicsURI alleviates tyrosine kinase inhibitors-induced ferroptosis by reprogramming lipid metabolism in p53 wild-type liver cancers. HEK293T cells were transfected with His-URI plasmid before anti-His immunoprecipitation and gel cutting. LC-MS/MS was performed to identify URI potential binding proteins.
URI keeps low levels of p53 in a TRIM28-MDM2 dependent manner, maintains SCD1 activity and accumulation of MUFAs, and subsequently promotes resistance to TKIs in cancer cell. URI-p53-SCD1 axis mediates resistance of TKIs and may explain why p53-wild type HCC still showed intrinsic resistance to TKIs...
ORGANISM(S): Homo sapiens (Human) 
2023-09-15 | PXD045407 | Pride
Uri 
UnknownDaphnane diterpenoid orthoesters with an odd-numbered aliphatic side chain from Daphne pedunculata.
Not available
S-EPMC11365762 | biostudies-literature
UnknownDaphnepedunins G and H, anti-HIV macrocyclic 3,4-seco-daphnane orthoesters from Daphne pedunculata.
Not available
S-EPMC10841610 | biostudies-literature
UnknownSCGN deficiency is a risk factor for autism spectrum disorder.
Not available
S-EPMC9806109 | biostudies-literature
ProteomicsThe role of Ptpn11E76K in MSC fate determination
MSCs expressing Ptpn11+/+ or Ptpn11E76K/+ were lysed for proteomic analysis. In brief, 0.5 μg of peptide mixture resolved in buffer A (0.1% formic acid) was loaded onto a 2‒cm self‒packed trap column using buffer A and separated on a 150 μm‒inner‒diameter column with a length of 15 cm over a 78‒min ...
ORGANISM(S): Mus Musculus 
2023-02-28 | PXD040487 |
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