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ProteomicsURI alleviates tyrosine kinase inhibitors-induced ferroptosis by reprogramming lipid metabolism in p53 wild-type liver cancers. HEK293T cells were transfected with His-URI plasmid before anti-His immunoprecipitation and gel cutting. LC-MS/MS was performed to identify URI potential binding proteins.
URI keeps low levels of p53 in a TRIM28-MDM2 dependent manner, maintains SCD1 activity and accumulation of MUFAs, and subsequently promotes resistance to TKIs in cancer cell. URI-p53-SCD1 axis mediates resistance of TKIs and may explain why p53-wild type HCC still showed intrinsic resistance to TKIs...
ORGANISM(S): Homo sapiens (Human) 
2023-09-15 | PXD045407 | Pride
Uri 
UnknownChange in colorectal cancer (CRC) testing rates associated with the introduction of the first organized screening program in canton Uri, Switzerland: Evidence from insurance claims data analyses from 2010 to 2018.
Not available
S-EPMC9218582 | biostudies-literature
TranscriptomicsExpression data from roots of WT and uri plants exposed to either Fe sufficient or Fe deficient conditions for 72 hours
We compared the gene expression in roots between WT and uri mutant under +Fe and -Fe conditions using ATH1 microarray analysis to explore which genes are affected by the loss of URI function.
ORGANISM(S): Arabidopsis thaliana 
2019-12-06 | GSE137201 | GEO
GenomicsChIP-seq data from roots of the uri complementation line exposed to either Fe sufficient or Fe deficient conditions for 72 hours
ChIP-seq data from roots of the uri complementation line exposed to either Fe sufficient or Fe deficient conditions for 72 hours
PRJNA566137 | ENA
GenomicsExpression data from roots of WT and uri plants exposed to either Fe sufficient or Fe deficient conditions for 72 hours
Expression data from roots of WT and uri plants exposed to either Fe sufficient or Fe deficient conditions for 72 hours
PRJNA564794 | ENA
TranscriptomicsGene expression profiling by bulk RNAseq from the livers of wild-type mice and those with loss-of-function mutations in URI 48 hours after partial hepatectomy
We used bulk RNA sequencing to examine the differentially expressed genes in the livers of URI loss-of-function mutant (specific deletion of URI in hepatocytes using serum albumin-creERT2 line) and wild-type littermate control mice 48 hours after partial hepatectomy (48H).
ORGANISM(S): Mus musculus 
2025-02-07 | GSE281923 | GEO
UnknownThe Expression of MicroRNA-598 Inhibits Ovarian Cancer Cell Proliferation and Metastasis by Targeting URI.
Not available
S-EPMC6325085 | biostudies-literature
GenomicsChIP-seq data from roots of the uri complementation line exposed to either Fe sufficient or Fe deficient conditions for 72 hours
We compared the URI binding to the chromosome in roots between +Fe and -Fe conditions.
ORGANISM(S): Arabidopsis thaliana 
2019-12-06 | GSE137645 | GEO
UnknownThe iron deficiency response in Arabidopsis thaliana requires the phosphorylated transcription factor URI.
Not available
S-EPMC6911256 | biostudies-literature
GenomicsGene expression profiling by bulk RNAseq from the livers of wild-type mice and those with loss-of-function mutations in URI 48 hours after partial hepatectomy
Gene expression profiling by bulk RNAseq from the livers of wild-type mice and those with loss-of-function mutations in URI 48 hours after partial hepatectomy
PRJNA1186183 | ENA
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