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ProteomicsImpact of whole-body versus nose-only exposure systems on systemic, respiratory, and cardiovascular endpoints in a 2-month cigarette smoke exposure study in the ApoE-/- mouse model [Lung data]
The objective of this study was to compare the biological and toxicological response of apolipoprotein E-deficient (Apoe-/-) mice to 3R4F mainstream smoke exposure for 2 months in whole-body exposure chambers (WBEC) and nose-only exposure chambers (NOEC). Female ApoE-/- mice were randomized into fou...
ORGANISM(S): Mus musculus (Mouse) 
2021-02-26 | PXD018185 | Pride
Lc-msms Mouse Lung Systems toxicology Itraq 
ProteomicsA Quantitative Chemical Proteomics Approach to Profile the Specific Cellular Targets of Andrographolide, a Promising Anticancer Agent that Suppresses Tumor Metastasis
Drug target identification is a critical step towards the understanding of the mechanism of action of a drug, which will help to improve the current therapeutic regime and to expand the drug’s therapeutic potential. However, current in vitro affinity chromatography-based and in vivo activity- based ...
ORGANISM(S): Homo sapiens (Human) 
2019-11-28 | PXD000588 | Pride
Chemical biology  drug targets*  itraq  mass spectrometry Molecular probes*   antitumor agents  metastasis 
UnknownDe Novo Variants in WDR37 Are Associated with Epilepsy, Colobomas, Dysmorphism, Developmental Delay, Intellectual Disability, and Cerebellar Hypoplasia.
Not available
S-EPMC6699142 | biostudies-literature
UnknownValidation and utility of ARDS subphenotypes identified by machine-learning models using clinical data: an observational, multicohort, retrospective analysis.
Not available
S-EPMC8976729 | biostudies-literature
UnknownPhysical activity attenuates the influence of FTO variants on obesity risk: a meta-analysis of 218,166 adults and 19,268 children.
Not available
S-EPMC3206047 | biostudies-literature
UnknownThe Influence of Age and Sex on Genetic Associations with Adult Body Size and Shape: A Large-Scale Genome-Wide Interaction Study.
Not available
S-EPMC4591371 | biostudies-literature
UnknownMulti-ancestry polygenic risk scores for the prediction of type 2 diabetes and complications in diverse ancestries.
Not available
S-EPMC12330429 | biostudies-literature
UnknownMulti-ancestry genetic study of type 2 diabetes highlights the power of diverse populations for discovery and translation.
Not available
S-EPMC9179018 | biostudies-literature
UnknownMulti-ancestry genome-wide study in >2.5 million individuals reveals heterogeneity in mechanistic pathways of type 2 diabetes and complications.
Not available
S-EPMC10081410 | biostudies-literature
UnknownGenetic drivers of heterogeneity in type 2 diabetes pathophysiology.
Not available
S-EPMC10937372 | biostudies-literature
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