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TranscriptomicsExpression data from five human leukemia cell lines treated with DMSO or tanshinone IIA
Tanshinone IIA (Tan IIA) is a diterpene quinone extracted from the root of Salvia miltiorrhiza, a Chinese traditional herb. Although previous studies have reported the anti-tumor effects of Tan IIA on various human cancer cells, the underlying mechanisms are not clear. We used microarrays to detail ...
ORGANISM(S): Homo sapiens 
2011-11-03 | E-GEOD-33358 | biostudies-arrayexpress
MetabolomicsTranscriptomics and metabolomics of engineered Synechococcus elongatus during photomixotrophic growth

BACKGROUND: Converting carbon dioxide (CO2) into value-added chemicals using engineered cyanobacteria is a promising strategy to tackle the global warming and energy shortage issues. However, most cyanobacteria are autotrophic and use CO2 as a sole carbon source, which makes it h...

2022-03-21 | MTBLS2825 | MetaboLights
UnknownMonoclonal antibodies targeting the HR2 domain and the region immediately upstream of the HR2 of the S protein neutralize in vitro infection of severe acute respiratory syndrome coronavirus.
Not available
S-EPMC1346840 | biostudies-literature
TranscriptomicsDeep sequencing identify tissue-specific microRNAs and their target genes involved in tanshinones biosynthesis in Salvia miltiorrhiza
Salvia miltiorrhiza is one of the most popular traditional medicinal herbs in Asian nations. Its dried root contains a number of tanshinones, protocatechuic aldehyde, salvianolic acid B and rosmarinic, and is used for the treatment of various diseases. To make clear the molecular mechanism of tanshi...
ORGANISM(S): Salvia miltiorrhiza 
2015-03-01 | E-GEOD-60757 | biostudies-arrayexpress
MetabolomicsTranscriptomic and Metabolomics Profiling of Phage–Host Interactions between Phage PaP1 and Pseudomonas aeruginosa
The basic biology of bacteriophage–host interactions has attracted increasing attention due to a renewed interest in the therapeutic potential of bacteriophages. In addition, knowledge of the host pathways inhibited by phage may provide clues to novel drug targets. However, the effect of phage on ba...
2018-05-03 | MTBLS431 | MetaboLights
UnknownExpression, glycosylation, and modification of the spike (S) glycoprotein of SARS CoV.
Not available
S-EPMC7120769 | biostudies-literature
UnknownA novel cell-based binding assay system reconstituting interaction between SARS-CoV S protein and its cellular receptor.
Not available
S-EPMC7112911 | biostudies-literature
TranscriptomicsHuman Embryonic Stem Cells on Biomatrices
Transcriptome profiling of undifferentiated H1 hESCs cultured on Matrigel, 293BM and 1112BM Biomatrices
ORGANISM(S): Homo sapiens 
2015-10-01 | E-MTAB-1647 | biostudies-arrayexpress
TranscriptomicsMicroarray analysis of the therapeutic effects of the mixture of salvianolic acids from Salvia miltiorrhiza and total flavonoids from Anemarrhena asphodeloides on sulfur mustard-induced damages
To further investigate the potential molecular basis of the therapeutic effects of the mixture of salvianolic acids from Salvia miltiorrhiza and total flavonoids from Anemarrhena asphodeloides (MSTF) on sulfur mustard (SM) damage, gene expression analysis was conducted on rats liver tissues using mi...
ORGANISM(S): Rattus norvegicus 
2014-11-05 | E-GEOD-62994 | biostudies-arrayexpress
ProteomicsMulti-Omics Analysis Reveals RNA Polymerase II Degradation as a Novel Mechanism of PF-3758309's Anti-Tumor Activity
In this study, we conducted a comprehensive multi-omics analysis, including proteomics, transcriptomics, and ubiquitinomics, to investigate the mechanism of PF-3758309 in HCT116 cells. Our results revealed that PF-3758309 promotes the degradation of RNA polymerase II subunit proteins (POLR2A/B/E) vi...
ORGANISM(S): Homo Sapiens 
2025-06-05 | PXD064705 |
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