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TranscriptomicsDNA methylation comparison of ntTS, TS and ES cells
Placental abnormalities occur frequently in cloned animals. To investigate DNA methylation profile of trophoblast cell lineage of somatic cell nuclear transferred (NT) embryos, we established TS cells from blastocysts produced by NT at the blastocyst stage. Three independent TS cell lines derived fr...
ORGANISM(S): Mus musculus 
2010-05-16 | E-GEOD-17104 | biostudies-arrayexpress
ProteomicsOntogenetic study of the composition of snake venom inhibitors and evaluation of the neutralizing activity of the gamma-type phospholipase inhibitor (γPLI) present in the plasma of Bothrops jararaca snake
Snake venom inhibitors have been studied for over a century. Among them are the plasma proteins of some mammals and of non-venomous and venomous snakes, which have the ability to promote resistance to the venom. These proteins have aroused biotechnological interest, as they are an excellent alternat...
ORGANISM(S): Bothrops jararaca (Jararaca) (Bothrops jajaraca) 
2024-05-21 | PXD034977 | Pride
Phospholipases a2  envenomation  pla2 inhibitor venomous snake 
ProteomicsComparative proteomics and biochemical analysis of venom of thirteen Bothrops moojeni specimens reveal several individual variations
Snake venoms are complex protein mixtures with different biological activities that can act in both their preys and human victims. Many of these proteins play a role in prey capture and in the digestive process of these animals. It is known that some snakes are resistant to the toxicity of their own...
ORGANISM(S): Bothrops moojeni 
2019-09-26 | PXD012585 | Pride
Bothrops moojeni  snake venom  envenomation  intraspecific venom variability  snake plasma 
ProteomicsFrom birth to adulthood: An analysis of Bothrops moojeni snake venom at different life stages
Bothrops moojeni has a wide distribution in Brazil and represents a serious medical concern at some localities. Previous works reported that the manifestations of snakebites caused by B. moojeni juveniles were mainly related to coagulation, while those caused by adults had more prominent local damag...
ORGANISM(S): Crotalus durissus terrificus Bothrops moojeni 
2021-06-24 | PXD024447 | Pride
Snake venom  bothrops moojeni  ontogeny  hdmse 
ProteomicsSnake venom color and LAAO: an evidence of long-term captive Crotalus durissus terrificus venom plasticity
The venom color variation of C. d. terrificus (Cdt) is attributed to the presence of the toxin LAAO. However, the driving mechanisms of such variability have not been studied and identified so far. During the venom milking routine at Butantan Institute, we have noticed that most of the venoms of cap...
ORGANISM(S): Crotalus durissus terrificus 
2023-10-23 | PXD019730 | Pride
Snake venom  crotalus durissus terrificus  snake venom plasticity  intraspecific venom variability  captivity maintenance  l-amino acid oxidase. 
UnknownPatient-reported dyspnea and health predict waitlist mortality in patients waiting for lung transplantation in Japan.
Not available
S-EPMC8061007 | biostudies-literature
ProteomicsEnhancing the bothropic antivenom through a reverse antivenomics approach
Antivenoms are the only effective treatment for snakebite envenomation and have saved countless lives over more than a century. Despite its value, antivenoms often present risks of adverse reactions. Current formulations contain a substantial fraction of non-specific antibodies and serum proteins th...
ORGANISM(S): Equus Caballus (ncbitaxon:9796) 
2024-11-07 | MSV000096324 | MassIVE
ProteomicsDIA-MS based proteome analysis of HL-60 cells treated with new anti-cancer drug (TAS4464)
We investigated the protein change of HL-60 cells with TAS4464 treatment in time series (0 h, 1h, 4h, 8h, 16h, 24h) by overlapping DIA-MS based proteome analysis. Spectral library was created by analyzing pooled samples by five gas-phase fractionated overlapping DIA-MS measurements.
ORGANISM(S): Homo Sapiens (human) 
PXD021012 | JPOST Repository
TranscriptomicsGene expression in cell cycle of Cyanidioschyzon merolae_1
To analyze mitotic cycle and organelle proliferation cycle, we investigated C.merolae cells across two cell cycles synchronized by light and dark cycles. C.merolae has one nucleus, mitochondria and chloroplast (Kuroiwa et al,1993. Protoplasma). Their division are strictly regulated by cell cycle and...
ORGANISM(S): Cyanidioschyzon merolae 
2010-05-19 | E-GEOD-8268 | biostudies-arrayexpress
ProteomicsLFQ of carboxymethyl/carboxyethyl lysine peptides from MGO- or GO-treated HeLa cells
HeLa cells (n=2) were treated with cell culture media containing 2 mM MGO or GO for 2 h and lysed in 6 M guanidine-HCl, 100 mM HEPES-NaOH, pH 7.5, 10 mM TCEP, and 40 mM CAA. The lysates were dissolved by heating and sonication, followed by centrifugation at 20,000 x g for 15 min at 4 ºC. The superna...
ORGANISM(S): Homo Sapiens (human) 
PXD063706 | JPOST Repository
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