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TranscriptomicsRNA sequencing analysis of DAF-16 target gene expression when math-33 function is genetically inactivated
In this study we have investigated the effect of loss of math-33 activity on DAF-16-mediated target gene regulation in C. elegans under conditions of reduced Insulin/IGF-1 signaling (IIS). Using whole nematode RNA sequencing experiments we found that the daf-2(e1370)-mediated induction and repressio...
ORGANISM(S): Caenorhabditis elegans 
2016-06-22 | E-GEOD-70117 | biostudies-arrayexpress
TranscriptomicsA protective strategy against hyperinflammatory responses requiring the non-transcriptional actions of GPS2
The association between hyper-inflammatory states and numerous diseases is widely recognized, but our understanding of the molecular strategies that have evolved to prevent uncontrolled activation of inflammatory responses remains incomplete. Here, we report a critical, non-transcriptional role of G...
ORGANISM(S): Homo sapiens 
2012-03-23 | E-GEOD-35197 | biostudies-arrayexpress
TranscriptomicsPHF8 mediates histone demethylation events in cell cycle progression [expression]
While reversible histone modifications are linked to an ever-expanding range of biological functions, the demethylases for histone H4 lysine 20 and their potential regulatory roles remain unknown. Here, we report that the PHD and Jumonji C (JmjC) domain-containing protein, PHF8, while utilizing mul...
ORGANISM(S): Homo sapiens 
2010-09-01 | E-GEOD-22477 | biostudies-arrayexpress
TranscriptomicsPHF8 mediates histone demethylation events in cell cycle progression
This SuperSeries is composed of the following subset Series: GSE22477: PHF8 mediates histone demethylation events in cell cycle progression [expression] GSE22478: PHF8 mediates histone demethylation events in cell cycle progression [ChIP-Seq] Refer to individual Series
ORGANISM(S): Homo sapiens 
2010-08-31 | E-GEOD-22400 | biostudies-arrayexpress
Transcriptomicssmall RNAnext Generation Sequencing of bone marrow-derived macrophages treated in M-CSF withdrawal medium
The goal of this study is to investigate the presence of novel small RNAs in apoptotic macrophage Method: cultured mouse (bl6 line) bone marrow were differentiated in for 7 days in conditioned medium, in preence of Macrophage-Colony Stimulating Factor (M-CSF). M-CSF also stimulates the survive of ma...
ORGANISM(S): Mus musculus 
2015-09-16 | E-GEOD-47408 | biostudies-arrayexpress
TranscriptomicsLncRNA-dependent mechanisms of androgen receptor-regulated gene activation programs
This SuperSeries is composed of the SubSeries listed below. Refer to individual Series
ORGANISM(S): Homo sapiens 
2013-08-15 | E-GEOD-47807 | biostudies-arrayexpress
TranscriptomicsLncRNA-dependent mechanisms of androgen receptor-regulated gene activation programs [ChIRP-seq]
While thousands of long non-coding RNAs (lncRNAs) are expressed in higher eukaryotes, the potential regulatory roles of lncRNAs in regulated gene transcription programs remain rather poorly understood. Here, we report that two lncRNAs highly overexpressed in aggressive prostate cancer, PRNCR1 and PC...
ORGANISM(S): Homo sapiens 
2013-08-15 | E-GEOD-47804 | biostudies-arrayexpress
TranscriptomicsLncRNA-dependent mechanisms of androgen receptor-regulated gene activation programs [GRO-seq II]
While thousands of long non-coding RNAs (lncRNAs) are expressed in higher eukaryotes, the potential regulatory roles of lncRNAs in regulated gene transcription programs remain rather poorly understood. Here, we report that two lncRNAs highly overexpressed in aggressive prostate cancer, PRNCR1 and PC...
ORGANISM(S): Homo sapiens 
2013-08-15 | E-GEOD-47806 | biostudies-arrayexpress
TranscriptomicsLncRNA-dependent mechanisms of androgen receptor-regulated gene activation programs [GRO-seq I]
While thousands of long non-coding RNAs (lncRNAs) are expressed in higher eukaryotes, the potential regulatory roles of lncRNAs in regulated gene transcription programs remain rather poorly understood. Here, we report that two lncRNAs highly overexpressed in aggressive prostate cancer, PRNCR1 and PC...
ORGANISM(S): Homo sapiens 
2013-08-15 | E-GEOD-47805 | biostudies-arrayexpress
GenomicsEnhancer-bound LDB1 Regulates a Corticotrope Promoter Pausing Repression Program [ChIP-seq]
Substantial evidence supports the hypothesis that enhancers are critical regulators of cell type determination, orchestrating both positive and negative transcriptional programs; however, the basic mechanisms by which enhancers orchestrate interactions with cognate promoters during activation and re...
ORGANISM(S): Mus musculus 
2015-02-03 | E-GEOD-64483 | biostudies-arrayexpress
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