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MetabolomicsXiao-Chai-Hu-Tang alleviates irinotecan-induced diarrhea via TGR5-FAK-RhoA/Rock signaling revealed by integrated metabolomics and proteomics

Irinotecan (CPT-11) is widely used for colorectal cancer treatment, with delayed-onset diarrhea as its primary side effect. Xiao-Chai-Hu-Tang (XCHT) has been clinically observed to alleviate diarrhea, but its mechanisms remain unclear. This study aimed to explore the underlying regulatory mechani...

2025-09-03 | MTBLS12931 | MetaboLights
MetabolomicsTracer-based Metabolomics Technology to Investigate the Role and Mechanism of Fangji Huangqi Tang in Regulating Lipid Metabolism Disorders in MPC-5 Cells
Lipid metabolism disorders play a critical role in the progression of nephrotic syndrome (NS). Although the traditional Chinese medicine formula Fangji Huangqi Tang (FHT) has been shown to restore lipid homeostasis in vivo, its specific molecular targets and effects on dynamic lipid metabolism in po...
2026-09-20 | MTBLS14277 | MetaboLights
ProteomicsProximity labeling identifies LOTUS domain proteins that promote the formation of perinuclear germ granules in C. elegans
Using C. elegans germ granule, called P granule, as a model system, we employed a proximity-based labeling method in combination with mass spectrometry to comprehensively define its protein components. This set of experiments identified over 200 proteins, many of which contain intrinsically disorder...
ORGANISM(S): Caenorhabditis elegans 
2021-11-11 | PXD027998 | Pride
Proximity labeling Germ granules C. elegans 
UnknownA double-blinded, placebo-controlled randomized trial evaluating the efficacy and safety of Zhigancao Tang granules for treating HFpEF: study protocol for a randomized controlled trial.
Not available
S-EPMC8056488 | biostudies-literature
UnknownMulti-omics reveals the impact of Clonorchis sinensis infection on mouse gut microbiota, metabolomics and transcriptomics.
Not available
S-EPMC12659621 | biostudies-literature
TranscriptomicsIdentification of genes responsive to mild hyperthermia in human cervical squamous cell carcinoma HeLa cells
Hyperthermia (HT) is widely used to treat patients with various cancers. In general, HT elicits a wide spectrum of stress responses such as induction of heat shock proteins, protein aggregation and cell death in mammalian cells. Although many biological processes are affected by HT, the overall resp...
ORGANISM(S): Homo sapiens 
2013-01-24 | E-GEOD-43701 | biostudies-arrayexpress
TranscriptomicsThe Fun30 ATP-dependent nucleosome remodeler promotes resection of DNA double-strand break ends
Chromosomal double-strand breaks (DSBs) are resected by 5M-bM-^@M-^Y-nucleases to form 3M-bM-^@M-^Y single-strand DNA (ssDNA) substrates for binding by homologous recombination and DNA damage checkpoint proteins. Two redundant pathways of extensive resection were described both in cells and in vitro...
ORGANISM(S): Saccharomyces cerevisiae 
2012-10-04 | E-GEOD-38601 | biostudies-arrayexpress
TranscriptomicsTSAR1 and TSAR2 activate triterpene saponin production in Medicago truncatula
We identified two novel transcription factors ‘Triterpene Saponin Activation Regulator’ (TSAR) 1 and 2 that each activate a specific branch of saponin synthesis in M. truncatula. Therefore we generated three independent TSAR1 and three independent TSAR2 overexpression (OE) hairy root lines. As a con...
ORGANISM(S): Medicago truncatula 
2017-02-15 | E-MTAB-3532 | biostudies-arrayexpress
MetabolomicsMulti-country metabolic signature discovery for chicken health classification

INTRODUCTION: To decrease antibiotic resistance, their use as growth promoters in the agricultural sector has been largely abandoned. This may lead to decreased health due to infectious disease or microbiome changes leading to gut inflammation.

OBJECTIVES: ...

2023-08-08 | MTBLS5065 | MetaboLights
TranscriptomicsTranscriptome profiling of irg1 mutant leaf of Medicago truncatula
To gain a molecular understanding of the loss-of-function mutation of a transcription factor involved in leaf morphogenesis impacts symmetric cuticular wax loading in M. truncatula, we compared the transcript profiles of wild-type R108 and three independent irg1/palm1 homozygous null mutant lines (i...
ORGANISM(S): Medicago truncatula 
2012-03-01 | E-MEXP-3190 | biostudies-arrayexpress
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