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GenomicsGadd45a promotes DNA demethylation through TDG
Growth arrest and DNA-damage-inducible protein 45 (Gadd45) family members have been implicated in DNA demethylation in vertebrates. However, it remained unclear how they contribute to the demethylation process. Here, we demonstrate that Gadd45a promotes active DNA demethylation through thymine DNA g...
ORGANISM(S): Mus musculus 
2015-05-07 | E-GEOD-62496 | biostudies-arrayexpress
TranscriptomicsSIRT6 regulates redox homeostasis in human mesenchymal stem cells by the transactivation of NRF2
We investigated the effect of SIRT6-knockout on gene expression and H3K4me3 modification profile in human mesenchymal stem cells. RNAs isolated from SIRT6+/+ and SIRT6-/- hMSCs at early and late passages were sequenced, respectively. And, H3K4me3 ChIP-seq was performed upon the SIRT6 deleted hMSC an...
ORGANISM(S): Homo sapiens 
2016-01-04 | E-GEOD-64642 | biostudies-arrayexpress
GenomicsA Werner syndrome stem cell model unveils heterochromatin alterations as a driver of human aging
Our data throw light upon the effect of WRN deficiency on gene expression and epigenomic modification, which indicates aging-associated changes from both genomic and epigenomic level. It was compared between WRN+/+ and WRN-/- in hESCs and hMSCs that the gene expression landscapes and epigenetic modi...
ORGANISM(S): Homo sapiens 
2015-05-13 | E-GEOD-52285 | biostudies-arrayexpress
ProteomicsProteomic profiling and molecular reclassification of high-grade serous ovarian cancer
In this study, we performed a comprehensive proteomic analysis of 116 primary tumor tissues from HGSOC patients. Our findings offer valuable insights into HGSOC’s molecular landscape, which could inform future biological studies, drug discovery, and the development of targeted therapies.
ORGANISM(S): Homo Sapiens 
2026-02-12 | PXD074808 |
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