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MetabolomicsMirabegron displays anticancer effects by globally browning adipose tissues

Metabolic reprogramming in malignant cells is a hallmark of cancer that relies on augmented glycolytic metabolism to support their growth, invasion and metastasis. However, the impact of global adipose metabolism on tumor growth and the drug development by targeting adipose metabolism remain larg...

2023-11-08 | MTBLS8682 | MetaboLights
ProteomicsRibosomal and tRNA Biogenesis Interact to Control Hypoxic Injury and Translation
Protein translation is an essential cellular process, but paradoxically, it can also promote aging and other stresses. In a screen for mutations that protect C. elegans from hypoxic stress, we isolated multiple genes that impact translation, including a ribosomal RNA helicase gene, ddx-52, tRNA bios...
ORGANISM(S): Caenorhabditis elegans 
2022-02-15 | PXD017267 | Pride
Ribosomal biogenesis Silac analysis of protein synthesis rate Lfq and tmt quantification Hypoxic sensitivity 
ProteomicsCsrA-controlled proteins important for Acinetobacter baumannii desiccation tolerance
Hospital environments serve as excellent reservoirs for the opportunistic pathogen Acinetobacter baumannii in part because it is exceptionally tolerant to desiccation. To understand the functional basis this trait, we used transposon sequencing (Tn-seq) to identify genes contributing to desiccatio...
ORGANISM(S): Acinetobacter baumannii AB5075 
2022-10-13 | PXD028391 | Pride
Acinetobacter baumannii Intrinsically disordered proteins Csra Desiccation Tn-seq 
ProteomicsMitochondrial interactome quantitation reveals structural changes in metabolic machinery in failing murine heart
Advancements of cross-linking mass spectrometry (XL-MS) for structural analysis of proteins bridges the gap between purified systems and native tissue environments. Here, we utilize isobaric quantitative protein interaction reporter technology (iqPIR) to further extend XL-MS to the first system-wide...
ORGANISM(S): Mus musculus (Mouse) 
2022-08-02 | PXD027757 | Pride
Quantitative cross-linking  heart failure  cardiac hypertrophy  mitochondria  protein interactions  interactome  mass spectrometry  systems structural biologyquantitative cross-linking  heart failure  cardiac hypertrophy  mitochondria  protein interactions  interactome  mass spectrometry  systems structural biology 
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