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GenomicsG-Quadruplex structures are stable and detectable in human genomic DNA.
The G-quadruplex is an alternative DNA structural motif that is considered to be functionally important in the mammalian genome. Herein, we address the hypothesis that G-quadruplex structures can exist within double-stranded genomic DNA using a G-quadruplex-specific probe. An engineered antibody is ...
ORGANISM(S): Homo sapiens 
2013-05-08 | E-GEOD-45241 | biostudies-arrayexpress
TranscriptomicsDSBCapture: in situ capture and direct sequencing of dsDNA breaks
Double-strand DNA breaks (DSBs) continuously arise and are a source of mutations and chromosomal rearrangements. Here, we present DSBCapture, a sequencing-based method that captures DSBs in situ and directly maps these at single nucleotide resolution enabling the study of DSB origin. DSBCapture show...
ORGANISM(S): Homo sapiens 
2016-07-18 | E-GEOD-78172 | biostudies-arrayexpress
TranscriptomicsChromatin immunoprecipitation and DNAse I hypersensitive site mapping of mouse hematopoietic cell lines and tissue-types to identify histone modification and transcription factor binding sites
Histone modification and transcription factor ChIP-chip in hematopoietic cell lines and tissue-types
ORGANISM(S): Mus musculus 
2008-09-30 | E-TABM-455 | biostudies-arrayexpress
TranscriptomicsG-quadruplex structures mark human regulatory chromatin
DNA secondary structures are important for fundamental genome functions such as transcription and replication1. The G-quadruplex (G4) structural motif has been linked to gene regulation2,3 and genome instability4,5 and may be important to cancer development and other diseases6-8. Recently, ~700,000 ...
ORGANISM(S): Homo sapiens 
2016-08-05 | E-GEOD-76688 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human leukocytes or whole blood isolated from burn/trauma subjects using either buffy coat or PAXgene methods
#G017 Burn/Trauma Study. This is a Glue Grant Study comparison between gene expression analyses performed in eight trauma/burn subjects using either a buffy coat isolation of whole blood or using the PAXgene system
ORGANISM(S): Homo sapiens 
2007-07-28 | E-GEOD-1343 | biostudies-arrayexpress
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