Sort   by:  
 Page size 
TranscriptomicsAutotaxin and its product lysophosphatidic acid suppress brown adipose differentiation and promote diet-induced obesity in mice
Brown adipose tissue (BAT) is a thermogenic organ that dissipates stored energy as heat to maintain body temperature in infants and small mammals. This process may also provide protection from development of diet-induced obesity. We found that the bioactive lipid mediator lysophosphatidic acid (LP...
ORGANISM(S): Mus musculus 
2011-06-01 | E-GEOD-26442 | biostudies-arrayexpress
MetabolomicsA Comprehensive and Ultrasensitive Isotope Calibration Method for Soil Amino Compounds Using Orbitrap Mass Spectrometry
Bound amino compounds (amino acid and amino sugar polymers) comprise a significant proportion (~40%) of soil organic nitrogen and therefore represent an essential source of nitrogen for plant and microbial nutrition. The analysis of their content and isotope enrichment still represents a significant...
2025-06-16 | MTBLS12550 | MetaboLights
TranscriptomicsProfiling downregulation of the mevalonate pathway in Staphylococcus aureus
Isoprenoids are a class of ubiquitous organic molecules synthesized from the five-carbon starter unit isopentenyl pyrophosphate (IPP). Comprising more than 30,000 known natural products, isoprenoids serve various important biological functions in many organisms. In bacteria, undecaprenyl pyrophospha...
ORGANISM(S): Staphylococcus aureus RN4220 
2010-05-05 | E-GEOD-13424 | biostudies-arrayexpress
UnknownChemokine Receptor 2 Targeted PET/CT Imaging Distant Metastases in Pancreatic Ductal Adenocarcinoma.
Not available
S-EPMC10789124 | biostudies-literature
ProteomicsAnalysis low level Hsp90 proteome by SILAC in yeast
Hsp90 is one of the most abundant and conserved proteins in the cell. Reduced levels or activity of Hsp90 causes defects in many cellular processes and also reveals genetic or non-genetic variation in populations. Despite information about Hsp90 protein-protein interactions, a global view of the Hsp...
ORGANISM(S): Saccharomyces cerevisiae (Baker's yeast) 
2014-10-24 | PXD001162 | Pride
Yeast Proteome Silac Hsp90 
ProteomicsCandidate proteins involved in the calyx abscission process of ‘Kuerlexiangli’ (Pyrus sinkiangensis Yu) identified by iTRAQ analysis
‘Kuerlexiangli’ (Pyrus sinkiangensis Yu) is an important market pear in China. The shape and quality of the fruit is negatively affected by the presence of a persistent calyx. Here, to explore the molecular mechanism of calyx abscission, we designed an experiment to compare protein expression at two...
ORGANISM(S): Pyrus x bretschneideri 
2020-06-17 | PXD012499 | Pride
Itraq Pear Calyx abscission Differentially abundant proteins 
TranscriptomicsInfluence of hyperthyroid conditions on gene expression in rat tibialis anterior
Extraocular muscles (EOMs) are a highly specialized type of tissue with a wide range of unique properties, including characteristic innervation, development, and structural proteins. Even though EOMs are frequently and prominently involved in thyroid-associated diseases, little is known about the im...
ORGANISM(S): Rattus norvegicus 
2009-03-06 | E-GEOD-13413 | biostudies-arrayexpress
ProteomicsA pipeline for discovery and verification of glycoproteins from plasma-derived extracellular vesicles as breast cancer biomarkers
Glycoproteins comprise more than half of current FDA-approved protein cancer markers but the development of new glycoproteins as disease biomarkers has been stagnant. Here we present a pipeline to develop glycoproteins from extracellular vesicles (EVs) through integrating quantitative glycoproteomic...
ORGANISM(S): Homo sapiens (Human) 
2018-04-26 | PXD007572 | Pride
Extracellular vesicles Glycoproteomics Biomarker 
ProteomicsPhosphoproteins in extracellular vehicles as candidate markers for breast cancer
The state of protein phosphorylation can be a key determinant of cellular physiology such as early stage cancer, but the development of phosphoproteins from biofluids for disease diagnosis remains elusive. Here we demonstrate, for the first time, a strategy to isolate and identify phosphoproteins in...
ORGANISM(S): Homo sapiens (Human) 
2017-03-23 | PXD005214 | Pride
Plasma Extracellular vesicles Phosphoproteomics Biomarker 
UnknownEpigenetic therapy using belinostat for patients with unresectable hepatocellular carcinoma: a multicenter phase I/II study with biomarker and pharmacokinetic analysis of tumors from patients in the Mayo Phase II Consortium and the Cancer Therapeutics Research Group.
Not available
S-EPMC3438233 | biostudies-literature
Sort   by:  
 Page size