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MetabolomicsSpermine is a natural suppressor of AR signaling in castration-resistant prostate cancer
In castration-resistant prostate cancer (CRPC), clinical response to androgen receptor (AR) antagonists is limited mainly due to AR-variants expression and restored AR signaling. The metabolite spermine is most abundant in prostate and it decreases as prostate cancer progresses, but its functions re...
2023-10-11 | MTBLS8034 | MetaboLights
ProteomicsThe proteomic changes in Pseudobagrus vachelli muscle and brain induced by hypoxia
The present NGST, TMT and Q-TOF MS platform should provide unprecedented resources to address such questions as to how hypoxic condition affects gene, miRNA, protein, and metabolite expression and changes the molecular pathways, and whether miRNAs participate in this process. For this purpose, we ch...
ORGANISM(S): Tachysurus Vachellii 
PXD020425 |
ProteomicsTemporal Proteomic and Lipidomic Profiles of Cerulein-Induced Acute Pancreatitis Reveals Novel Insights for Metabolic Alterations in the Disease Pathogenesis
The pathophysiological mechanisms of acute pancreatitis (AP) are complex and have remained a mystery to date, but metabolism is gradually recognized as an important driver of AP onset and development. We used a cerulein-induced AP mouse model to conduct LC-MS/MS based time-course proteomics and lipi...
ORGANISM(S): Mus Musculus 
2022-12-06 | PXD038567 |
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