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MetabolomicsPeripheral modulation of antidepressant targets MAO-B and GABAAR by harmol induces mitohormesis and delays aging in preclinical models
Reversible and sub-lethal stresses to the mitochondria elicit a program of compensatory responses that ultimately improve mitochondrial function, a conserved anti-aging mechanism termed mitohormesis. Here, we show that harmol, a member of the beta-carbolines family with anti-depressant properties, i...
2023-05-26 | MTBLS7533 | MetaboLights
ProteomicsLabel-free based DIA quantification of a lung cancer cell line and its potential application in nanomedicine.
Lung cancer is the uncontrolled growth of abnormal cells in the lungs, which can form tumors and interfere with the functioning of the lung. This disease is registered worldwide as the most common type of cancer in men as well as the most common cause of death; besides lung cancer mortality in women...
ORGANISM(S): Homo sapiens (Human) 
2022-08-19 | PXD015405 | Pride
Mrc5 Mass spectrometry Small cell lung cancer Label-free H69ar 
UnknownPsychosocial factors partially explain gender differences in health-related quality of life in heart failure patients.
Not available
S-EPMC10053343 | biostudies-literature
GenomicsNuclear DICKKOPF-1 as a biomarker of chemoresistance and poor clinical outcome in colorectal cancer
Sporadic colorectal cancer (CRC) insurgence and progression depend on the activation of Wnt/?-catenin signaling. Dickkopf (DKK)-1 is an extracellular inhibitor of Wnt/?-catenin signaling that also has undefined ?-catenin-independent actions. Here we report for the first time that a proportion of DKK...
ORGANISM(S): Homo sapiens 
2015-05-13 | E-GEOD-31170 | biostudies-arrayexpress
UnknownGenetic variants and clinical determinants affecting the response to 5-Fluorouracil-based treatment in Chilean patients with advanced colorectal cancer
Not available
S-EPMC12331468 | biostudies-literature
UnknownGlobal, regional, and national disease burden estimates of acute lower respiratory infections due to respiratory syncytial virus in young children in 2015: a systematic review and modelling study.
Not available
S-EPMC5592248 | biostudies-literature
UnknownEffect of Direct Transportation to Thrombectomy-Capable Center vs Local Stroke Center on Neurological Outcomes in Patients With Suspected Large-Vessel Occlusion Stroke in Nonurban Areas: The RACECAT Randomized Clinical Trial.
Not available
S-EPMC9073661 | biostudies-literature
UnknownPresentation, care, and outcomes of patients with NSTEMI according to World Bank country income classification: the ACVC-EAPCI EORP NSTEMI Registry of the European Society of Cardiology.
Not available
S-EPMC10495699 | biostudies-literature
UnknownA prognostic model for use before elective surgery to estimate the risk of postoperative pulmonary complications (GSU-Pulmonary Score): a development and validation study in three international cohorts.
Not available
S-EPMC12056793 | biostudies-literature
UnknownEffects of hospital facilities on patient outcomes after cancer surgery: an international, prospective, observational study.
Not available
S-EPMC9210173 | biostudies-literature
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