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GenomicsHistone H3 lysine 9 di-methylation as an epigenetic signature of the interferon response (sequencing)
Effective anti-viral immunity depends on the ability of infected cells or cells triggered with virus-derived nucleic acids to produce type I interferon (IFN), which activates transcription of numerous antiviral genes. However, disproportionately strong or chronic IFN expression is a common cause of ...
ORGANISM(S): Mus musculus 
2012-03-02 | E-GEOD-22102 | biostudies-arrayexpress
TranscriptomicsGene expression data from hippocampus, striatum, hypothalamus cortex, Drd2-MSNs and Drd1-MSNs in mice
Goal of the experiment: Analysis of gene expression changes in the cortex, striatum, hippocampus, hypothalamus, Drd2-MSNs and Drd1-MSNs of mice with a postnatal, neuron-specific ablation of GLP or G9a as compared to control mice. For microarray analysis, hippocampus, hypothalamus, cortex and striatu...
ORGANISM(S): Mus musculus 
2009-12-10 | E-GEOD-19402 | biostudies-arrayexpress
TranscriptomicsMicroarray analysis of striatal tissue of wild type and Ezh1/Ezh2 dKO mice at 6 weeks, 3 months, and 6 months
Normal brain function critically depends on the interaction between highly specialized neurons that operate within anatomically and functionally distinct brain regions. The fidelity of neuronal specification is contingent upon the robustness of the transcriptional program that supports the neuron ty...
ORGANISM(S): Mus musculus 
2016-07-29 | E-GEOD-84243 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mouse BAFF-stimulated B cells
The aim of the study was to illucidate how BAFF mediates B cell survival and growth through the identification of BAFF-regulated genes. Experiment Overall Design: RNA was isolated from unstimulated B cells ("minus") or after 36 hours of treatment with 25 ng/ml of BAFF ("plus"). A fraction of cell ly...
ORGANISM(S): Mus musculus 
2008-06-14 | E-GEOD-5985 | biostudies-arrayexpress
TranscriptomicsTo determine the global gene expression response in murine LPS-induced macrophages treated with a bromodomain inhibitor.
Bone marrow-derived macrophages, Unstimulated DMSO Bone marrow-derived macrophages, Unstimulated + I-BET (GSK525762A) Bone marrow-derived macrophages, LPS 1h DMSO Bone marrow-derived macrophages, LPS 1h + I-BET (GSK525762A) Bone marrow-derived macrophages, LPS 2h DMSO Bone marrow-derived macrophages...
ORGANISM(S): Mus musculus 
2010-11-10 | E-GEOD-21764 | biostudies-arrayexpress
TranscriptomicsHistone H3 lysine 9 di-methylation as an epigenetic signature of the interferon response (WT and G9a deficient MEFs)
Effective anti-viral immunity depends on the ability of infected cells or cells triggered with virus-derived nucleic acids to produce type I interferon (IFN), which activates transcription of numerous antiviral genes. However, disproportionately strong or chronic IFN expression is a common cause of ...
ORGANISM(S): Mus musculus 
2012-03-02 | E-GEOD-24776 | biostudies-arrayexpress
TranscriptomicsHistone H3 lysine 9 di-methylation as an epigenetic signature of the interferon response (WT and G9a deficient DCs)
Effective anti-viral immunity depends on the ability of infected cells or cells triggered with virus-derived nucleic acids to produce type I interferon (IFN), which activates transcription of numerous antiviral genes. However, disproportionately strong or chronic IFN expression is a common cause of ...
ORGANISM(S): Mus musculus 
2012-03-02 | E-GEOD-24774 | biostudies-arrayexpress
GenomicsHigh density copy number analysis and whole exome sequencing of diffuse large B-cell lymphoma

Diffuse Large B-cell Lymphoma (DLBCL) represents the most common form of B-cell non-Hodgkin Lymphoma (B-NHL), accounting for ~30% of the de-novo diagnoses and also arising as a frequent clinical evolution of Follicular Lymphoma (FL). The molecular pathogenesis of DLBCL is associated with multip...

phs000328.v1.p1 | EGA
TranscriptomicsAnalysis of global gene expression profiles of hPAF1 deficient A549 cells during infection with H1N1 influenza A virus or vesicular stomatitis virus (VSV)
Viral infection is commonly associated with virus-driven hijacking of host proteins. We describe a novel mechanism by which influenza virus impacts host cells through the interaction of influenza NS1 protein with the infected cell epigenome. We show that the NS1 protein of influenza A H3N2 targets t...
ORGANISM(S): Homo sapiens 
2012-02-15 | E-GEOD-35266 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of lymph node T cells isolated from Ezh2fl/fl or Ezh2 deficient mice to study the role of ezh2 on actin polymerization and cell signaling
Lymph node T cells isolated from Ezh2fl/fl or Ezh2 deficient mice
ORGANISM(S): Mus musculus 
2007-11-22 | E-GEOD-1566 | biostudies-arrayexpress
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