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MetabolomicsInulin gel-mediated delivery of Clostridium butyricum spores protects against acute kidney injury via regulation of ER-mitochondria contacts
Acute kidney injury (AKI) progression is closely associated with gut microbiota dysbiosis. However, the detailed mechanism remains unclear. In this study, we found that patients with AKI had decreased beneficial bacteria and reduced butyric acid levels in the intestine. Furthermore, butyrate allevia...
2026-09-17 | MTBLS15607 | MetaboLights
MetabolomicsComprehensive High-Resolution Multiple-Reaction Monitoring Mass Spectrometry for Targeted Eicosanoid Assays
Eicosanoids comprise a class of bioactive lipids derived from a unique group of essential fatty acids that mediate a variety of important physiological functions. Owing to the structural diversity of these lipids, their analysis in biological samples is often a major challenge. Advancements in mass ...
2018-06-26 | MTBLS641 | MetaboLights
MetabolomicsMechanisms of action of bile acids in pediatric gastroesophageal reflux: Exploration through non-targeted and targeted metabolomics methods

Purpose: To investigate the pathogenesis of pediatric bile reflux gastritis (BRG) using non-targeted and targeted metabolomics analyses of the changes and content differences of bile acids (BAs) in gastric juice. Methods: Data from 25 pediatric BRG patients treat...

2025-12-05 | MTBLS13459 | MetaboLights
MetabolomicsMechanisms of action of bile acids in pediatric gastroesophageal reflux: Exploration through non-targeted and targeted metabolomics methods

Purpose: To investigate the pathogenesis of pediatric bile reflux gastritis (BRG) using non-targeted and targeted metabolomics analyses of the changes and content differences of bile acids (BAs) in gastric juice. Methods: Data from 25 pediatric BRG patients treated at Jinhua Maternal and Child He...

2025-12-04 | MTBLS13450 | MetaboLights
GenomicsTargeted Delivery of Selective BET Inhibitors
Targeted Delivery of Selective BET Inhibitors
PRJNA1169909 | ENA
MetabolomicsThe targeted metabolomics data of the post-term mouse model

We performed targeted metabolomics analysis on placental tissues from post term mouse models generated by double knockout of steroid hormone receptor coactivators 1 and 2, as well as from wild type mouse placentas. The levels of polyamines (putrescine, spermidine and spermine) and amino acids (ci...

2026-05-14 | MTBLS14423 | MetaboLights
GenomicsTherapeutic Delivery of Targeted Nanoparticle Cannabinoid Equivalents
Therapeutic Delivery of Targeted Nanoparticle Cannabinoid Equivalents
PRJNA849515 | ENA
UnknownTumor-targeted delivery of siRNA using fatty acyl-CGKRK peptide conjugates.
Not available
S-EPMC5522445 | biostudies-literature
MetabolomicsDual-Targeted Microspheres Reshape the Metabolic-immune Microenvironment and Reverse Multiple Dilemmas Post-embolization in Hepatocellular Carcinoma

Transarterial embolization (TAE) efficacy in hepatocellular carcinoma (HCC) is limited by post-embolization hypoxia-driven angiogenesis and metabolic reprogramming. To address these challenges, pH-responsive gelatin microspheres encapsulating zinc sulfide (ZnS) nanoparticles (ZnS@GMs) were develo...

2026-02-09 | MTBLS13720 | MetaboLights
GenomicsTargeted immunosuppression enhances repeated gene delivery
Targeted immunosuppression enhances repeated gene delivery
PRJNA823700 | ENA
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