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MetabolomicsLC-MS/MS-based targeted metabolomics profiling of central carbon metabolites in Candida albicans SC5314 under control and treatment conditions
Targeted LC-MS/MS metabolomics was performed to profile central carbon and related metabolites in Candida albicans SC5314. Six samples from control and treatment groups were analyzed using UPLC-QTRAP 6500+ in scheduled MRM mode. Data were quantified with MultiQuant and analyzed using PCA, OPLS-DA, d...
2026-07-08 | MTBLS14973 | MetaboLights
MetabolomicsLC-MS/MS targeted analysis of ferroptosis-associated phospholipid peroxidation in KIF11-depleted HRECs

Human retinal vascular endothelial cells (HRECs) were transfected with lentivirus encoding either KIF11-targeting shRNA or a non-targeting control. KIF11-depleted and control cells were then subjected to lipid extraction followed by LC–MS/MS–based targeted analysis of ferroptosis-associated phosp...

2026-02-13 | MTBLS12912 | MetaboLights
MetabolomicsLC-MS/MS Quantification of Nuclear α-KG in NSCLC
This study contains targeted LC-MS/MS quantification of α-ketoglutarate (α-KG) in NSCLC cells using 13C-labeled α-KG internal standard. Nuclear α-KG levels were measured in A549, A549/DTX, PC9, and PC9/OR cells. In addition, nuclear α-KG was quantified in GLUD1-overexpressing A549 cells and GLUD1-kn...
2026-07-21 | MTBLS15115 | MetaboLights
MetabolomicsTargeted LC-MS/MS metabolomics of in vitro cultured Rothia mucilaginosa supernatant (tryptophan and short-chain fatty acid panels)
Targeted LC-MS/MS (MRM) metabolomics of in vitro cultured Rothia mucilaginosa:a tryptophan-pathway panel and a short-chain fatty acid panel comparing culture supernatant with medium controls. Raw mzML files are deposited.
2026-10-06 | MTBLS15044 | MetaboLights
MetabolomicsTargeted metabolomics analysis by LC-MS/MS for BMDCs infected with VSV
Virus-infected cells often exhibit dramatic cellular changes accompanied by altered mitochondrial function. The contribution of factors shaping the inner mitochondrial membrane (IMM) and cristae architecture on viral replication is insufficiently understood. Single cell transcriptomics applying vesi...
2025-06-18 | MTBLS12438 | MetaboLights
MetabolomicsLC-MS/MS metabolomics unravels the resistant phenotype of carbapenemase-producing Enterobacteriaceae

Introduction: The degree of antimicrobial resistance demonstrated by carbapenemase-producing Enterobacteriaceae (CPE) represents a growing public health challenge. Conventional methods for detecting CPE involve culture-based techniques with lengthy incubation steps. There is a ne...

2025-08-04 | MTBLS10129 | MetaboLights
MetabolomicsOrgan-Resolved Untargeted LC-MS/MS Profiling of Putative Metabolite Families in Aerial Organs of Vitex negundo L

Background/Objectives: Vitex negundo L. is a multi-part medicinal and aromatic plant, but organ-resolved chemical information for its aerial organs remains incomplete. This study generated an exploratory paired untargeted liquid chromatography–tandem mass spectrometry (LC-MS/MS) dataset for flowe...

2026-09-13 | MTBLS15653 | MetaboLights
MetabolomicsTargeted LC-MS/MS Analysis of Soluble Metabolites in the MeOH:H2O Phase (part-IV)
Not available
ORGANISM(S): Synechocystis sp. PCC 6803 
ST001198 | MetabolomicsWorkbench
MetabolomicsNon-targeted metabolomics screen comparing metabolite profiles of serum from PDAC-bearing mice that received metronidazole using high-resolution, high-performance LC-MS/MS analysis.
Not available
ORGANISM(S): Mus musculus 
ST002216 | MetabolomicsWorkbench
MetabolomicsBridging Targeted (Zeno MRM-HR) and Untargeted (SWATH) LC–HRMS in a Single Run for Sensitive Exposomics

Traditionally, chemical exposure has been assessed by low-resolution mass spectrometry via targeted approaches due to the typically extremely low concentration of such compounds in biological samples. Nevertheless, untargeted approaches are now becoming a promising tool for a broader investigatio...

2025-08-28 | MTBLS10565 | MetaboLights
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