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MetabolomicsTargeting STK39 ameliorates cardiac remodeling by Improving Mitochondrial function through degradation of IFIT3

Pathological cardiac remodeling in response to sustained pressure overload is a pivotal process in the progression of heart failure (HF), yet the underlying molecular mechanisms remain incompletely understood, limiting therapeutic development. Here, we identify serine/threonine kinase 39 (STK39) ...

2026-09-28 | MTBLS15834 | MetaboLights
ProteomicsTargeted KRAS(G12V) degradation elicits efficient and durable lung adenocarcinoma regression in vivo
Recent drug discovery breakthroughs led to the approval of KRASG12C inhibitors in lung adenocarcinoma (LUAD). Unfortunately, clinical responses remain limited due to rapid resistance onset. Proteolysis-targeting chimeras (PROTACs) have emerged as promising alternatives to traditional inhibition. How...
ORGANISM(S): Mus musculus (Mouse) 
2026-05-13 | PXD058734 | Pride
Mouse models Targeted protein degradation in vivo Resistance Llung adenocarcinoma Kras Protacs 
MetabolomicsAnalysis of Growth Phases of Enterotoxigenic Escherichia coli Reveals a Distinct Transition Phase before Entry into Early Stationary Phase with Shifts in Tryptophan, Fucose, and Putrescine Metabolism and Degradation of Neurotransmitter Precursors

Enterotoxigenic Escherichia coli (ETEC) is a major cause of diarrhea in children and adults in endemic areas. Gene regulation of ETEC during growth in vitro and in vivo needs to be further evaluated, and here we describe the full transcriptome and metabolome of ETEC dur...

2022-07-15 | MTBLS3540 | MetaboLights
Metabolomics13C glucose labelling studies using 2D NMR is a useful tool for determining ex vivo whole organ metabolism during hypothermic machine perfusion of kidneys
Background: The aim of this study is to determine the feasibility of using Nuclear Magnetic Resonance (NMR) tracer studies (13C-enriched glucose) to detect ex vivo de novo metabolism in the perfusion fluid and cortical tissue of porcine kidneys during hypothermic machine perfusion (HMP). Methods: Po...
2017-10-16 | MTBLS367 | MetaboLights
ProteomicsDiscovery of a CNS active GSK3 degrader using orthogonally reactive linker screening
Bifunctional targeted protein degraders, also known as Proteolysis Targeting Chimeras (PROTACs), are an emerging drug modality that may offer a new approach to understand and treat neurodegenerative diseases. These molecules have a non-occupancy based, sub-stoichiometric mechanism of action which re...
ORGANISM(S): Homo sapiens (Human) 
2025-10-13 | PXD065662 | Pride
Central nervous system Targeted protein degradation Direct-to-biology Glycogen synthase kinase 3 
TranscriptomicstRNAs marked with CCACCA are targeted for degradation
The CCA-adding enzyme adds CCA to the 3' ends of transfer RNAs (tRNAs), a critical step in tRNA biogenesis that generates the amino acid attachment site. We found that the CCA-adding enzyme plays a key role in tRNA quality control by selectively marking unstable tRNAs and tRNA-like small RNAs for de...
ORGANISM(S): Saccharomyces cerevisiae 
2011-11-17 | E-GEOD-33756 | biostudies-arrayexpress
UnknownA selective and orally bioavailable VHL-recruiting PROTAC achieves SMARCA2 degradation in vivo.
Not available
S-EPMC9551036 | biostudies-literature
ProteomicsDiscovery of a CNS active GSK3 degrader using orthogonally reactive linker screening
Bifunctional targeted protein degraders, also known as Proteolysis Targeting Chimeras (PROTACs), are an emerging drug modality that may offer a new approach to understand and treat neurodegenerative diseases. These molecules have a non-occupancy based, sub-stoichiometric mechanism of action which re...
ORGANISM(S): Homo sapiens (Human) 
2025-10-13 | PXD065692 | Pride
Central nervous system Targeted protein degradation Glycogen synthase kinase 3 
ProteomicsDiscovery of a CNS active GSK3 degrader using orthogonally reactive linker screening
Bifunctional targeted protein degraders, also known as Proteolysis Targeting Chimeras (PROTACs), are an emerging drug modality that may offer a new approach to understand and treat neurodegenerative diseases. These molecules have a non-occupancy based, sub-stoichiometric mechanism of action which re...
ORGANISM(S): Mus musculus (Mouse) 
2025-10-13 | PXD065740 | Pride
Targeted protein degradation Central nervous system Glycogen synthase kinase 3 Direct-to-biology 
ProteomicsDiscovery of a CNS active GSK3 degrader using orthogonally reactive linker screening
Bifunctional targeted protein degraders, also known as Proteolysis Targeting Chimeras (PROTACs), are an emerging drug modality that may offer a new approach to understand and treat neurodegenerative diseases. These molecules have a non-occupancy based, sub-stoichiometric mechanism of action which re...
ORGANISM(S): Mus musculus (Mouse) 
2025-10-13 | PXD065731 | Pride
Targeted protein degradation Central nervous system Glycogen synthase kinase 3 Direct-to-biology 
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