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TranscriptomicsInduction of IL-17+ T-cells by HIV-Tat protein is mediated via Vascular Endothelial Growth Factor Receptor-2
Anti-retroviral therapy (ART) has transformed human immunodeficiency virus (HIV) infection from a fatal illness to a chronic condition by controlling viral replication and restoring immune function. However, chronic T-cell activation can be observed in 20-35% of individuals on ART, resulting in an i...
ORGANISM(S): Homo sapiens 
2013-08-02 | E-GEOD-44460 | biostudies-arrayexpress
TranscriptomicsChIP-chip from KG-1 cells with HIV Tat
HIV-1 Tat can modulate the expression of both HIV and cellular genes. In antigen-presenting cells Tat induces the expression of a subset of interferon-stimulated genes (ISGs) in the absence of interferons (IFNs). We investigated the genome-wide Tat association with cellular promoters in immature den...
ORGANISM(S): Homo sapiens 
2013-05-31 | E-GEOD-42191 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human lymphocyte response to E. coli to identify any transcriptional component to the protection in vitro bacterially induced PBMC apoptosis
Sepsis induces lymphocyte apoptosis which can be prevented by over-expression of anti-apoptotic Bcl-2 family members. The anti-apoptotic activity of Bcl-2 family members is localized in the BH4 domain. The therapeutic peptide, TAT-BH4, was found to prevent sepsis-induced lymphocyte apoptosis in vi...
ORGANISM(S): Homo sapiens 
2006-02-07 | E-MEXP-555 | biostudies-arrayexpress
ProteomicsDynamics of the Escherichia coli proteome in response to the deletion of the Tat pathway
In Escherichia coli, the Twin-arginine (Tat) secretion system is one of the main routes of the protein export to the periplasm. The Tat pathway secretes a set of proteins with important physiological functions. In our study, we investigated the influence of the deactivation of the Tat pathway on the...
ORGANISM(S): Escherichia coli 
2019-02-18 | PXD008803 | Pride
Escherichia coli Stress responses Tat pathway 
TranscriptomicsTat controls RNA Polymerase II and the epigenetic landscape to precisely rewire cellular transcriptional programs (RNA-Seq)
Transcription factors mediate precise regulation of gene expression programs to modulate key biological processes. In addition to controlling HIV transcription, Tat appears to modulate cellular transcription to alter the biology of target immune cells and generate a permissive state for HIV infecti...
ORGANISM(S): Homo sapiens 
2015-06-15 | E-GEOD-65688 | biostudies-arrayexpress
TranscriptomicsTranscriptomic and phenotypic analysis reveals new functions for the Tat pathway in Yersinia pseudotuberculosis [dtatC-vs-ip_26C-log]
The Twin-arginine translocation (Tat) system promotes secretion of folded proteins that in bacteria are identified via an N-terminal signal peptide. Tat systems are associated with virulence in many bacterial pathogens and our previous studies revealed that Tat deficient Yersinia pseudotuberculosis ...
ORGANISM(S): Yersinia pseudotuberculosis IP 32953 
2016-07-01 | E-GEOD-80528 | biostudies-arrayexpress
ProteomicsIdentification of HIV Tat and NF-kB binding proteins associated with semen derived extracellular vesicles. In this study, we used orthogonal pull-downs, mobility shift, and electrophoretic protein binding assays coupled with proteomic and secretomic analyses to highlights the previously unappreciated SEV-associated transcriptional repressors that may target HIV Tat to suppress viral transcription.
Semen-derived extracellular vesicles (SEVs) have been shown to inhibit the human immunodeficiency virus type 1 (HIV-1) LTR transactivation through the blockade of the interaction of transactivator of transcription (Tat) and host transcription factors NF-kB and Sp1 (Tat•NF-ᴋB p65 and Tat•Sp1). The ab...
ORGANISM(S): Homo sapiens (Human) 
2026-06-15 | PXD062816 | Pride
Hiv Extracellular vesicles Tat Nfkb 
ProteomicsIdentification of HIV Tat and NF-kB binding proteins associated with semen derived extracellular vesicles In this study, we used orthogonal pull-downs, mobility shift, and electrophoretic protein binding assays coupled with proteomic and secretomic analyses to highlights the previously unappreciated SEV-associated transcriptional repressors that may target HIV Tat to suppress viral transcription.
Semen-derived extracellular vesicles (SEVs) have been shown to inhibit the human immunodeficiency virus type 1 (HIV-1) LTR transactivation through the blockade of the interaction of transactivator of transcription (Tat) and host transcription factors NF-kB and Sp1 (Tat•NF-ᴋB p65 and Tat•Sp1). The ab...
ORGANISM(S): Homo sapiens (Human) 
2026-06-15 | PXD062784 | Pride
Hiv Extracellular vesicles Tat Nfkb 
TranscriptomicsTranscriptomic and phenotypic analysis reveals new functions for the Tat pathway in Yersinia pseudotuberculosis [dtatC-vs-ip_37C-log]
The Twin-arginine translocation (Tat) system promotes secretion of folded proteins that in bacteria are identified via an N-terminal signal peptide. Tat systems are associated with virulence in many bacterial pathogens and our previous studies revealed that Tat deficient Yersinia pseudotuberculosis ...
ORGANISM(S): Yersinia pseudotuberculosis IP 32953 
2016-07-01 | E-GEOD-80530 | biostudies-arrayexpress
TranscriptomicsTranscriptomic and phenotypic analysis reveals new functions for the Tat pathway in Yersinia pseudotuberculosis [dtatC-vs-ip_26C-stat]
The Twin-arginine translocation (Tat) system promotes secretion of folded proteins that in bacteria are identified via an N-terminal signal peptide. Tat systems are associated with virulence in many bacterial pathogens and our previous studies revealed that Tat deficient Yersinia pseudotuberculosis ...
ORGANISM(S): Yersinia pseudotuberculosis IP 32953 
2016-07-01 | E-GEOD-80529 | biostudies-arrayexpress
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