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TranscriptomicsInduction of IL-17+ T-cells by HIV-Tat protein is mediated via Vascular Endothelial Growth Factor Receptor-2
Anti-retroviral therapy (ART) has transformed human immunodeficiency virus (HIV) infection from a fatal illness to a chronic condition by controlling viral replication and restoring immune function. However, chronic T-cell activation can be observed in 20-35% of individuals on ART, resulting in an i...
ORGANISM(S): Homo sapiens 
2013-08-02 | E-GEOD-44460 | biostudies-arrayexpress
TranscriptomicsHIV-1 Tat protein promotes neuronal dysfunction through disruption of microRNAs.
Over the last decade, small noncoding RNA molecules such as microRNAs (miRNAs) have emerged as critical regulators in the expression and function of eukaryotic genomes. It has been suggested that viral infections and neurological disease outcome may also be shaped by the influence of small RNAs. Thi...
ORGANISM(S): Homo sapiens 
2013-02-12 | E-GEOD-44265 | biostudies-arrayexpress
GenomicsThe PhoP-dependent ncRNA Mcr7 modulates the TAT secretion system in Mycobacterium tuberculosis [ChIP-Seq]
The PhoPR two-component system is essential for virulence in Mycobacterium tuberculosis where it controls expression of approximately 2% of the genes, including those for the ESX-1 secretion apparatus, a major virulence determinant. Mutations in phoP lead to compromised production of pathogen-specif...
ORGANISM(S): Mycobacterium tuberculosis H37Rv 
2014-06-02 | E-GEOD-54239 | biostudies-arrayexpress
TranscriptomicsThe PhoP-dependent ncRNA Mcr7 modulates the TAT secretion system in Mycobacterium tuberculosis [RNA-Seq]
The PhoPR two-component system is essential for virulence in Mycobacterium tuberculosis where it controls expression of approximately 2% of the genes, including those for the ESX-1 secretion apparatus, a major virulence determinant. Mutations in phoP lead to compromised production of pathogen-specif...
ORGANISM(S): Mycobacterium tuberculosis H37Rv 
2014-06-02 | E-GEOD-54240 | biostudies-arrayexpress
TranscriptomicsHuman Immunodeficiency Virus Tat Directly Interacts with a Specific Set of Cellular RNAs
We have used RNA immunoprecipitation to identify the set of mRNAs that HIV-1 Tat interacts with in T-cells. We have also performed measurements of relative RNA abundance to determine if Tat binding is associated with an increase in RNA abundance in Tat-expressing T-cells and during HIV infection of ...
ORGANISM(S): Homo sapiens 
2013-11-05 | E-MEXP-3199 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human lymphocyte response to E. coli to identify any transcriptional component to the protection in vitro bacterially induced PBMC apoptosis
Sepsis induces lymphocyte apoptosis which can be prevented by over-expression of anti-apoptotic Bcl-2 family members. The anti-apoptotic activity of Bcl-2 family members is localized in the BH4 domain. The therapeutic peptide, TAT-BH4, was found to prevent sepsis-induced lymphocyte apoptosis in vi...
ORGANISM(S): Homo sapiens 
2006-02-07 | E-MEXP-555 | biostudies-arrayexpress
TranscriptomicsThe PhoP-dependent ncRNA Mcr7 modulates the TAT secretion system in Mycobacterium tuberculosis
This SuperSeries is composed of the SubSeries listed below. Refer to individual Series
ORGANISM(S): Mycobacterium tuberculosis H37Rv 
2014-06-02 | E-GEOD-54241 | biostudies-arrayexpress
TranscriptomicsHIV-1 TAT SUPPRESSES THE TCR/CD3 MACHINERY IN HUMAN CD4+ T CELLS [Tat]
Our previous work demonstrated that HIV-1 infection progressively reduces TCR/CD3 expression due to a defect in CD3g gene transcripts. We further found that knocking down expression of the viral tat and/or nef genes was correlated with CD3g transcript and TCR/CD3 surface receptor levels on HIV-1 inf...
ORGANISM(S): Homo sapiens 
2015-12-31 | E-GEOD-33705 | biostudies-arrayexpress
TranscriptomicsTat controls RNA Polymerase II and the epigenetic landscape to precisely rewire cellular transcriptional programs (RNA-Seq)
Transcription factors mediate precise regulation of gene expression programs to modulate key biological processes. In addition to controlling HIV transcription, Tat appears to modulate cellular transcription to alter the biology of target immune cells and generate a permissive state for HIV infecti...
ORGANISM(S): Homo sapiens 
2015-06-15 | E-GEOD-65688 | biostudies-arrayexpress
TranscriptomicsHIV-1 Tat protein promotes neuronal dysfunction through disruption of microRNAs
Over the last decade, small noncoding RNA molecules such as microRNAs (miRNAs) have emerged as critical regulators in the expression and function of eukaryotic genomes. It has been suggested that viral infections and neurological disease outcome may also be shaped by the influence of small RNAs. Thi...
ORGANISM(S): Homo sapiens 
2012-12-07 | E-GEOD-42423 | biostudies-arrayexpress
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