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ProteomicsHuman serum proteome of low-dose radiation area
Two sampling areas were focused in this study; Tande tande hamlet as high-level natural background radiation area (HBRA) and Topoyo sub-district as normal level background radiation area (NBRA), which was done under coordination with Local Health Office. The former located in 2° 44’ 38.3’’ south lat...
ORGANISM(S): Homo Sapiens (human) 
2022-05-12 | PXD025946 | JPOST Repository
ProteomicsQuantification of oxidative modification of human serum albumin by MRM-HR
Two sampling areas were focused in this study; Tande tande hamlet as high-level natural background radiation area (HBRA) and Topoyo sub-district as normal level background radiation area (NBRA), which was done under coordination with Local Health Office. The former located in 2° 44’ 38.3’’ south lat...
ORGANISM(S): Homo Sapiens (human) 
2022-05-12 | PXD025947 | JPOST Repository
ProteomicsProteomics analysis of mouse-derived bone marrow cells exposed to a lethal level of ionizing radiation
The precipitated proteins from whole cells were resuspended in 50 μl of 500 mM ammonium bicarbonate containing 8 M urea, and reduced with 5 μl of 200 mM DTT. The samples were incubated at 90°C for 30 min and cooled to room temperature. Free cysteine residues were alkylated with 10 μl of 200 mM iodoa...
ORGANISM(S): Mus Musculus (mouse) 
2022-05-12 | PXD025953 | JPOST Repository
ProteomicsIdentification of oxidative modification of mouse serum albumin
After a week of acclimatization, 8-week-old mice were randomly divided into 4 groups consisting of more than 8 mice per group, and subjected to varying total body irradiation (TBI) doses of 0, 0.5, 1 or 3 Gy of X-rays (150 kVp, 20 mA, 0.5-mm aluminum and 0.3-mm copper filters) at a dose rate of 1.0 ...
ORGANISM(S): Mus Musculus (mouse) 
2022-05-12 | PXD025948 | JPOST Repository
ProteomicsQuantification of oxidative modification of mouse serum albumin by MRM-HR
After a week of acclimatization, 8-week-old mice were randomly divided into 4 groups consisting of more than 8 mice per group, and subjected to varying total body irradiation (TBI) doses of 0, 0.5, 1 or 3 Gy of X-rays (150 kVp, 20 mA, 0.5-mm aluminum and 0.3-mm copper filters) at a dose rate of 1.0 ...
ORGANISM(S): Mus Musculus (mouse) 
2022-05-12 | PXD025949 | JPOST Repository
ProteomicsSWATH-MS analysis of x-ray radiated mouse serum
After a week of acclimatization, 8-week-old mice were randomly divided into 4 groups consisting of more than 8 mice per group, and subjected to varying total body irradiation (TBI) doses of 0, 0.5, 1 or 3 Gy of X-rays (150 kVp, 20 mA, 0.5-mm aluminum and 0.3-mm copper filters) at a dose rate of 1.0 ...
ORGANISM(S): Mus Musculus (mouse) 
2022-05-12 | PXD025950 | JPOST Repository
ProteomicsProteomic analysis of the survival effect of TPO receptor agonist Romiplostim treatment in mice exposed to a lethal dose of radiation
Background: The thrombopoietin receptor agonist romiplostim (RP) is a therapeutic agent for immune thrombocytopenia that can achieve complete survival in mice exposed to a lethal dose of ionizing radiation. The estimated mechanism of the radio-protective/mitigative effects of RP has been proposed; h...
ORGANISM(S): Mus Musculus (mouse) 
2021-05-12 | PXD025921 | JPOST Repository
ProteomicsIntranasal administration of balenine alleviates neurodegeneration and inflammation in a mouse model of Parkinson’s disease
Imidazole dipeptides (IDPs) have physiological properties, including antioxidant, pH-buffering, and metal ion chelating activities. Carnosine, an IDP, shows promise for treating neurodegenerative diseases, including Parkinson’s disease (PD). However, carnosine-degrading enzymes limit its bioavailabi...
ORGANISM(S): Mus Musculus (mouse) 
2026-06-05 | PXD065872 | JPOST Repository
ProteomicsPancreatic cancer proteome from paraffin-embedded tissue
Formalin fixed paraffin-embedded pancreas tissues were deparaffinized by two changes of xylene and washed with descending concentrations of ethanol. Proteins in the deparaffinized tissues were extracted in 20%(w/v) of 200 mM Tris-HCl (pH 8.8) containing 2% SDS and 0.2 M DTT followed by incubation at...
ORGANISM(S): Homo Sapiens (human) 
2021-10-27 | PXD025975 | JPOST Repository
ProteomicsMitochondrial proteome of ES1 KO mouse brain
Mitochondrial fraction was obtained using the mitochondrial isolation kit (KC010100, BioChain Institute). Each tissue was finely chopped and homogenized 40 strokes in two volumes of mitochondrial isolation buffer, and then centrifuged at 600×g for 10 min. The supernatant was collected and centrifuge...
ORGANISM(S): Mus Musculus (mouse) 
2022-05-12 | PXD025954 | JPOST Repository
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