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ProteomicsProteomics of human tau-transgenic mice reveals protein modules associated with tau pathologies
Abnormally accumulated tau protein aggregates are one of the hallmarks of dementia, including Alzheimer’s disease (AD), and are believed to play a critical role in neurodegeneration. In order to investigate proteomic alteration driven by tau aggregates, we implemented quantitative proteomics to anal...
ORGANISM(S): Mus Musculus (mouse) 
PXD031129 | JPOST Repository
ProteomicsPhosphorylated Tau Interactome in the Human Alzheimers Disease Brain
Accumulation of phosphorylated tau is a key pathological feature of Alzheimers disease. Phosphorylated tau accumulation causes synaptic impairment, neuronal dysfunction and formation of neurofibrillary tangles. The pathological actions of phosphorylated tau are mediated by surrounding neuronal prote...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2020-04-17 | MSV000085305 | MassIVE
GenomicsSIRT6-CBP dependent Nuclear Tau Accumulation and its Role in Protein Synthesis.
SIRT6-CBP dependent Nuclear Tau Accumulation and its Role in Protein Synthesis.
PRJNA719152 | ENA
ProteomicsA pilot study for deciphering post-translational modifications and proteoforms of tau protein by capillary electrophoresis-mass spectrometry
Abnormal accumulation of tau proteins is one pathological hallmark of Alzheimer’s disease (AD). Many tau protein post-translational modifications (PTMs) are associated with the development of AD, such as phosphorylation, acetylation, and methylation. Therefore, a complete picture of PTM landscape of...
ORGANISM(S): Escherichia coli 
2024-10-15 | PXD053367 | Pride
Alzheimer’s disease Capillary electrophoresis-mass spectrometry Post-translational modification Tau protein Phosphorylation Proteoform 
TranscriptomicsAlzheimer's Disease Dataset
FK506 binding protein 51kDa (FKBP51/FKBP5) is part of a mature heat shock protein 90kDa (Hsp90) chaperone complex that preserves tau. Microarray analysis of human brains reveal that FKBP51 gene expression selectively increased with age and Alzheimer's disease, which correlated with demethylation of ...
ORGANISM(S): Homo sapiens 
2014-04-21 | E-GEOD-48350 | biostudies-arrayexpress
GenomicsTau accumulation induces microglial state alterations in Alzheimer’s disease model mice (Spatial Transcriptomics)
Tau accumulation induces microglial state alterations in Alzheimer’s disease model mice (Spatial Transcriptomics)
PRJNA1126288 | ENA
TranscriptomicsLCM-based microarray analysis of neuronal vulnerability in the mouse model of Sanfilippo syndrome (MPSIIIB)
Sanfilippo syndrome type B (MPS III B) is an autosomal recessive, neurodegenerative disease of children, characterized by profound mental retardation and dementia. The primary cause is mutation in the NAGLU gene, resulting in deficiency of N-acetylglucosaminidase and lysosomal accumulation of hepara...
ORGANISM(S): Mus musculus 
2009-04-22 | E-GEOD-15758 | biostudies-arrayexpress
GenomicsTau accumulation induces microglial state alterations in Alzheimer’s disease model mice (snRNA-seq, part 2)
Tau accumulation induces microglial state alterations in Alzheimer’s disease model mice (snRNA-seq, part 2)
PRJNA1126290 | ENA
GenomicsTau accumulation induces microglial state alterations in Alzheimer’s disease model mice (snRNA-seq, part 1)
Tau accumulation induces microglial state alterations in Alzheimer’s disease model mice (snRNA-seq, part 1)
PRJNA1126291 | ENA
TranscriptomicsSIRT6-CBP dependent Nuclear Tau Accumulation and its Role in Protein Synthesis.
Several neurodegenerative diseases present Tau accumulation as the main pathological marker. Tau post-translational modifications such as phosphorylation and acetylation are increased in neurodegenerative patients. Here, we show that Tau hyper-acetylation at residue 174 increases its own nuclear pre...
ORGANISM(S): Homo sapiens 
2021-04-02 | GSE171342 | GEO
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