Tauopathies - OmicsDI

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Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA 02215, USA., Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA 02115, USA (1)
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Dept. of Anatomy and Neurobiology, Dept. of Pharmacology, Physiology and Biophysics and Dept. of Neurology, Boston University School of Medicine, Boston, MA (1)

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Specific post-translational modifications of the soluble tau protein distinguish between Alzheimer’s disease, 4R-, and 3R-tauopathies

The tau protein aggregates in several neurodegenerative disorders, referred to as tauopathies. The type of tau isoforms (4R/3R) observed in brain aggregates is used to classify tauopathies. However, distinguishing tauopathies in cerebrospinal fluid remains challenging. Here, we demonstrated that the...

ORGANISM(S): Homo sapiens (Human)

2023-06-22 | PXD038901 | Pride

Dysregulation of RNA splicing in tauopathies

PRJNA430221 | ENA

Analysis of pathological tau associated with a wide range of tauopathies

We have analyzed and compared the post-translational modifications in the pathological tau proteins prepared from a wide range of tauopathies.

ORGANISM(S): Homo Sapiens (human)

2020-07-15 | PXD020371 | JPOST Repository

Increased G3BP2-Tau interaction in Tauopathies is a natural defense against Tau aggregation

PRJNA940831 | ENA

Dysregulation of RNA splicing in tauopathies

Pathological aggregation of RNA binding proteins (RBPs) has emerged as an important driver of multiple neurodegenerative diseases. Since RBP aggregation may result in a loss of normal RBP function, we examined whether dysregulation of RNA metabolism contributes to tauopathies. We find that the PS19 ...

ORGANISM(S): Mus musculus

2019-11-13 | GSE109226 | GEO

Tauopathies: new perspectives and challenges.

Not available

S-EPMC8991707 | biostudies-literature

Tauopathies as clinicopathological entities.

Not available

S-EPMC4662611 | biostudies-literature

Clinical Spectrum of Tauopathies.

Not available

S-EPMC9329580 | biostudies-literature

Tau and MAPT genetics in tauopathies and synucleinopathies.