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GenomicsRole of DNMT3B in the regulation of early neural and neural crest specifiers
The de novo DNA methyltransferase DNMT3B functions in establishing DNA methylation patterns during development. We performed RNAi knockdown of DNMT3B in human embryonic stem cells (ESCs) in order to investigate the mechanistic contribution of DNMT3B on DNA methylation and early neuronal differentiat...
ORGANISM(S): Homo sapiens 
2012-03-27 | E-GEOD-32268 | biostudies-arrayexpress
TranscriptomicsRNA-seq of pancreatic CAF-derived cell line 0082T treated with Autotaxin inhibitors (IOA-289 and PF-8380) against DMSO treated controls
Autotaxin (ATX), encoded by ENPP2, catalyzes the production of lysophosphatidic acid (LPA), an important regulator within the tumor microenvironment (TME). ATX is a clinical target in pancreatic ductal adenocarcinoma (PDAC), yet the pro-tumorigenic action of the ATX/LPA axis in PDAC remains unclear....
ORGANISM(S): Homo sapiens 
2024-10-06 | E-MTAB-14494 | biostudies-arrayexpress
UnknownWound irrigation does not affect health-related quality of life after open fractures: results of a randomized controlled trial.
Not available
S-EPMC6413805 | biostudies-literature
UnknownOptimization of Metformin in the GRADE Cohort: Effect on Glycemia and Body Weight.
Not available
S-EPMC7171946 | biostudies-literature
UnknownAre large clinical trials in orthopaedic trauma justified?
Not available
S-EPMC5909275 | biostudies-literature
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