Optimization of Metformin in the GRADE Cohort: Effect on Glycemia and Body Weight.

ABSTRACT:

Objective

We evaluated the effect of optimizing metformin dosing on glycemia and body weight in type 2 diabetes.

Research design and methods

This was a prespecified analysis of 6,823 participants in the Glycemia Reduction Approaches in Diabetes: A Comparative Effectiveness Study (GRADE) taking metformin as the sole glucose-lowering drug who completed a 4- to 14-week (mean ± SD 7.9 ± 2.4) run-in in which metformin was adjusted to 2,000 mg/day or a maximally tolerated lower dose. Participants had type 2 diabetes for <10 years and an HbA_1c ≥6.8% (51 mmol/mol) while taking ≥500 mg of metformin/day. Participants also received diet and exercise counseling. The primary outcome was the change in HbA_1c during run-in.

Results

Adjusted for duration of run-i

SUBMITTER: Sivitz WI 

PROVIDER: S-EPMC7171946 | biostudies-literature | 2020 May

REPOSITORIES: biostudies-literature