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TranscriptomicsNative functions of the androgen receptor are essential to pathogenesis in a Drosophila model of spinobulbar muscular atrophy
Spinobulbar muscular atrophy (SBMA) is a neurodegenerative disease caused by expansion of a polyglutamine tract in the androgen receptor (AR). This mutation confers toxic function to AR through unknown mechanisms. Mutant AR toxicity requires binding of its hormone ligand, suggesting that pathogenesi...
ORGANISM(S): Drosophila melanogaster 
2010-09-23 | E-GEOD-23802 | biostudies-arrayexpress
TranscriptomicsMiRNA expression in adipose tissue and liver from a spontaneous rat model of Type 2 diabetes
MicroRNAs (miRNAs) are non-coding RNA molecules involved in post-transcriptional control of gene expression of a wide number of genes, including those involved in glucose homeostasis. Type 2 diabetes (T2D) is characterized by hyperglycaemia and defects in insulin secretion and action at target tissu...
ORGANISM(S): Rattus norvegicus 
2010-05-16 | E-GEOD-17058 | biostudies-arrayexpress
TranscriptomicsValidation of EZH2 targets in GSCs treated with shNT (control), shMELK, shFOXM1, and EZH2 overexpression
We demonstrate that the catalytic subunit of Polycomb Repressive Complex 2, EZH2, is targeted by the MELK-FOXM1 complex, which in turn promotes resistance to radiation in GSCs. Clinically, EZH2 and MELK are co-expressed in GBM and significantly induced in post-irradiation recurrent tumors whose expr...
ORGANISM(S): Homo sapiens 
2015-04-16 | E-GEOD-63963 | biostudies-arrayexpress
TranscriptomicsTranscriptome of the maturing erythroblast
Understanding the pattern of gene expression and identifying the specific genes expressed during erythropoiesis is crucial for a synthesis of erythroid developmental biology. Here we have isolated four distinct populations of erythroblasts at successive erythropoietin-dependent stages of erythropoie...
ORGANISM(S): Homo sapiens 
2011-03-02 | E-GEOD-22552 | biostudies-arrayexpress
TranscriptomicsCustom MHC array analysis of lymphoblastoid cell lines
The human MHC is a paradigm for genomics, showing striking association with disease but functional variants remain largely unresolved. Using an original hybrid microarray (containing tiling and junction probes) for the MHC and accounting for known sequence diversity, we have drawn the first high-res...
ORGANISM(S): Homo sapiens 
2011-05-23 | E-GEOD-22453 | biostudies-arrayexpress
TranscriptomicsThe Populus transciptome in elevated CO2 reveals increased anthocyanin biosynthesis during delayed autumnal senescence
Over recent decades the progression of natural autumnal senescence has been increasingly delayed across wide areas of the Northern Hemisphere and is thought to be caused by rising temperature. Recently this delay has been shown to be partly attributable to rising atmospheric carbon dioxide concentr...
ORGANISM(S): Populus x canadensis 
2010-01-31 | E-GEOD-15874 | biostudies-arrayexpress
TranscriptomicsExpression in adipose tissue and liver from a spontaneous rat model of Type 2 diabetes
This SuperSeries is composed of the following subset Series: GSE17058: MiRNA expression in adipose tissue and liver from a spontaneous rat model of Type 2 diabetes GSE17059: Gene expression in adipose tissue and liver from a spontaneous rat model of Type 2 diabetes Refer to individual Series
ORGANISM(S): Rattus norvegicus 
2010-05-16 | E-GEOD-17060 | biostudies-arrayexpress
TranscriptomicsSCGB3A2 suppresses bleomycin-induced pulmonary fibrosis through activation of STAT1 and up-regulation of SMAD7
We report for the first time that secretoglobin (SCGB) 3A2, a novel cytokine-like molecule, predominantly expressed in pulmonary airways epithelium, drastically reduced the severity of lung fibrosis using bleomycin-induced mouse model. DNA microarrays were performed using RNAs isolated from mouse lu...
ORGANISM(S): Mus musculus 
2011-04-30 | E-GEOD-21560 | biostudies-arrayexpress
TranscriptomicsHuman medulloblastoma samples
Purpose Integrated genomics approaches have identified at least four distinct biological variants in medulloblastoma: WNT, SHH, group C, and group D. Non-WNT/Non-SHH tumors are associated with metastatic dissemination and an unfavorable prognosis. Additional markers may enhance outcome prediction in...
ORGANISM(S): Homo sapiens 
2011-07-01 | E-GEOD-28245 | biostudies-arrayexpress
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