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TranscriptomicsGenomics of medulloblastoma identifies four distinct molecular variants
Recent genomic approaches have suggested the existence of multiple distinct subtypes of medulloblastoma. We studied a large cohort of medulloblastomas to determine how many subgroups of the disease exist, how they differ, and the extent of overlap between subgroups. We determined gene expression p...
ORGANISM(S): Homo sapiens 
2010-09-13 | E-GEOD-21140 | biostudies-arrayexpress
UnknownGenome-Wide DNA Methylation Analysis Reveals Epigenetic Dysregulation of MicroRNA-34A in TP53-Associated Cancer Susceptibility.
Not available
S-EPMC6366343 | biostudies-literature
ProteomicsMetabolic Regulation of the Epigenome Drives Lethal Infantile Ependymoma
PFA ependymomas are a lethal glial malignancy of the hindbrain found in babies and toddlers. Lacking any highly recurrent somatic mutations, PFAs have been proposed as a largely epigenetically driven tumor type. An almost complete lack of model systems has inhibited discovery of novel PFA therapies....
ORGANISM(S): Homo sapiens (Human) 
2020-08-13 | PXD018191 | Pride
Proteomics H3k27 methylation and acetylation Pfa ependymomas 
UnknownLigand discovery and virtual screening using the program LIDAEUS.
Not available
S-EPMC2268042 | biostudies-literature
UnknownBRAF mutation and CDKN2A deletion define a clinically distinct subgroup of childhood secondary high-grade glioma.
Not available
S-EPMC4356711 | biostudies-literature
TranscriptomicsThe blood transcriptional signature of chronic HCV [Affymetrix data]
This study characterizes the effects of chronic Hepatitis C virus (HCV) infection on gene expression by analyzing blood samples from 10 treatment-naive HCV patients and 6 healthy volunteers. Differential expression analysis of microarray data from peripheral blood mononuclear cells (PBMCs) identifie...
ORGANISM(S): Homo sapiens 
2012-10-22 | E-GEOD-40184 | biostudies-arrayexpress
TranscriptomicsThe blood transcriptional signature of chronic HCV [Illumina data]
This study characterizes the effects of chronic Hepatitis C virus (HCV) infection on gene expression by analyzing blood samples from 10 treatment-naive HCV patients and 6 healthy volunteers. Differential expression analysis of microarray data from peripheral blood mononuclear cells (PBMCs) identifie...
ORGANISM(S): Homo sapiens 
2012-10-22 | E-GEOD-40223 | biostudies-arrayexpress
ProteomicsPrtg+ve Rhombic Lip Ventricular Zone Stem Cells Initiate and Maintain Group 3 Medulloblastoma
PRTG+ve cells show high self renewability in Group 3 medulloblastoma tumors. To access the proteins differentially expressed in this subset of cells, we sorted PRTG+ve and PRTG-ve cells by surface staining with Anti-PRTG antibody from Gr3 medulloblastoma xenografts.
ORGANISM(S): Homo sapiens (Human) 
2024-07-31 | PXD034890 | Pride
Tumor initiating cells Car t cell therapy Medulloblastoma Group 3 Rhombic lip Cell of origin 
UnknownThe N-terminal region of DNMT3A engages the nucleosome surface to aid chromatin recruitment.
Not available
S-EPMC11624362 | biostudies-literature
UnknownAntibody-based methods for the measurement of α-synuclein concentration in human cerebrospinal fluid - method comparison and round robin study.
Not available
S-EPMC6587944 | biostudies-literature
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