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UnknownUstilago maydis produces itaconic acid via the unusual intermediate trans-aconitate.
Not available
S-EPMC4720413 | biostudies-literature
TranscriptomicsLPS stimulation of human PBMC-derived macrophages
Immunoresponsive gene 1 (IRG1) is one of the highest induced genes in macrophages under pro-inflammatory conditions and its function has been recently described: it codes for immune-responsive gene 1 protein/cis-aconitic acid decarboxylase (IRG1/CAD), an enzyme catalyzing the production of itaconic ...
ORGANISM(S): Homo sapiens 
2016-02-25 | E-GEOD-76561 | biostudies-arrayexpress
ProteomicsA new NO-independent immunomodulatory function for iNOS in regulating itaconate production via mitochondrial protein-protein interaction with IRG1
iNOS modulates itaconate metabolism by a novel conformation-dependent protein-protein interaction separate from iNOS-mediated NO generation.
ORGANISM(S): Homo sapiens (Human) 
2026-02-20 | PXD048712 | Pride
Macrophages Tca cycle by cis-aconitate decarboxylase Inos and irg1 
UnknownItaconic acid is a mammalian metabolite induced during macrophage activation.
Not available
S-EPMC3216473 | biostudies-literature
UnknownTargeting the ACOD1-itaconate axis stabilizes atherosclerotic plaques.
Not available
S-EPMC10848031 | biostudies-literature
UnknownMetabolic engineering of Shewanella oneidensis to produce glutamate and itaconic acid.
Not available
S-EPMC10771365 | biostudies-literature
UnknownItaconate Alters Succinate and Coenzyme A Metabolism via Inhibition of Mitochondrial Complex II and Methylmalonyl-CoA Mutase.
Not available
S-EPMC7922098 | biostudies-literature
MetabolomicsPFKFB3 activates CAD to enhance de novo pyrimidine synthesis for cell growth

Aerobic glycolysis, termed the Warburg effect, is one of the aberrant metabolic pathways in highly proliferating cells. Glycolysis provides glycolytic metabolites to support the generation of biomass, such as nucleotides, amino acids, and lipids. To date, research on the direct interactions betwe...

2025-07-08 | MTBLS12688 | MetaboLights
TranscriptomicsTranscriptomic Modulation by Exosomes Derived from Human Adipose Stem Cells in Neuronal Cells
Exosomes derived from human adipose tissue mesenchymal stem cells (hASCs) have demonstrated anti-inflammatory and rejuvenating properties, making them promising agents for neurochemical intervention. However, their transcriptomic impact on neuronal cells remains largely unexplored. To address this r...
ORGANISM(S): Mus musculus 
2025-10-17 | E-MTAB-15753 | biostudies-arrayexpress
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