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TranscriptomicsExpression of SUDHL-1 cell line treated by ALK inhibitors
In this study we compared the effects of ALK inhibitor on the gene expression, activation of cell signaling pathways, and functional properties of cells derived from a patient with Anaplastic Large Cell Lymphoma. we used microarrays to map the genome-wide gene expression patterns in ALK+TCL cells in...
ORGANISM(S): Homo sapiens 
2013-10-31 | E-GEOD-50803 | biostudies-arrayexpress
UnknownCrystal structure of MTCP-1: implications for role of TCL-1 and MTCP-1 in T cell malignancies.
Not available
S-EPMC19850 | biostudies-literature
UnknownCharacterization of the TCL-1 transgenic mouse as a preclinical drug development tool for human chronic lymphocytic leukemia.
Not available
S-EPMC1895879 | biostudies-literature
TranscriptomicsCombining MCL-1 Inhibition and CD37-directed CAR T Cells as an Effective Strategy to Target T-cell Lymphoma
Chimeric antigen receptor (CAR) T cell therapy has not yet been realized for T-cell lymphomas (TCL), partially due to challenges in identifying tumor-specific antigens. We previously reported selective expression of CD37 on malignant T cells in a subset of TCL. Herein, we demonstrate CAR-37 T cells ...
ORGANISM(S): Homo sapiens 
2025-07-30 | GSE287873 | GEO
TranscriptomicsDifferential gene expression of T-cell lymphomas (TCL) upon engagement of T-cell receptor (TCR) signaling [TCL1; T8ML1]
To study differential gene expression of TCLs upon TCR signaling, three TCL primary cells and one TCL cell line T8ML1 were chosen for this study. The prmiary TCL cells consist of TCL1 and TCL2 (sezary patients) and TCL3 (PTCL, NOS patient). The TCR signaling was engaged by anti-CD3/CD28 treatment in...
ORGANISM(S): Homo sapiens 
2017-02-10 | GSE77875 | GEO
GenomicsCDK9 is a Dependency in GATA-3 driven and MCL-1 independent T-cell Lymphomas [ChIP-seq]
The transcription factor GATA-3 is a proto-oncogene in subsets of mature T cell lymphomas (TCL). CDK9 is a transcriptional regulator that, by phosphorylating paused RNA polymerase II (RNAPII), enables efficient transcriptional elongation. Therefore, we were motivated to examine the extent to which C...
ORGANISM(S): Homo sapiens 
2025-11-28 | GSE296537 | GEO
TranscriptomicsCDK9 is a Dependency in GATA-3 driven and MCL-1 independent T-cell Lymphomas [RNA-seq]
The transcription factor GATA-3 is a proto-oncogene in subsets of mature T cell lymphomas (TCL). CDK9 is a transcriptional regulator that, by phosphorylating paused RNA polymerase II (RNAPII), enables efficient transcriptional elongation. Therefore, we were motivated to examine the extent to which C...
ORGANISM(S): Homo sapiens 
2025-11-28 | GSE296506 | GEO
UnknownCombining MCL-1 inhibition and CD37-directed chimeric antigen receptor T cells as an effective strategy to target T-cell lymphoma.
Not available
S-EPMC12463675 | biostudies-literature
UnknownT cell leukemia I oncogene expression depends on the presence of Epstein-Barr virus in the virus-carrying Burkitt lymphoma lines.
Not available
S-EPMC153638 | biostudies-literature
UnknownTargeting JAK/STAT Signaling Antagonizes Resistance to Oncolytic Reovirus Therapy Driven by Prior Infection with HTLV-1 in Models of T-Cell Lymphoma.
Not available
S-EPMC8310324 | biostudies-literature
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