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ProteomicsESK1 and MAGE-A4 TCR-like antibody immunoprecipitation in human liver tissue
We chose to perform a head-to-head immune-enrichment from primary liver tissue resections using both, MAGE-A4 and ESK1 TCR-like antibodies. Since both target antigens MAGE-A4 and WT-1 are not expressed in hepatocytes (Human Protein Atlas, www.proteinatlas.org), the ESK1 enrichment could serve as iso...
ORGANISM(S): Homo sapiens (Human) 
2024-03-30 | PXD048294 | Pride
Hla Tcr-like antibody Bispecific antibody Immunopeptidomics 
ProteomicsMAGE-A4 TCR-like antibody immunoprecipitation in A375 and A375 MAGE-A4 KO xenograft tissue
To demonstrate the on-target binding of the MAGE-A4 antibody to the target HLAp GVYDGREHTV, we developed a reverse immunopeptidomics strategy that uses the HLAp-targeting antibody as a bait to enrich interacting HLAp from A375 xenografts. For this purpose, we immobilized the IgG-format of the MAGE-A...
ORGANISM(S): Homo sapiens (Human) 
2024-04-02 | PXD048298 | Pride
Tcr-like antibody Human tissue Immunopeptidomics 
ProteomicsMAGE-A4 TCR-like antibody immunoprecipitation in A375 and A375 MAGE-A4 KO xenograft tissue
To demonstrate the on-target binding of the MAGE-A4 antibody to the target HLAp GVYDGREHTV, we developed a reverse immunopeptidomics strategy that uses the HLAp-targeting antibody as a bait to enrich interacting HLAp from A375 xenografts. For this purpose, we immobilized the IgG-format of the MAGE-A...
ORGANISM(S): Homo sapiens (Human) 
2024-03-30 | PXD048297 | Pride
Tcr-like antibody Human tissue Immunopeptidomics 
ProteomicsMAGE-A4 TCR-like antibody IP in human lung and colon tissue
We chose to perform immune-enrichment from primary lung and colon tissue resections using both, anti-MAGE-A4 in IgG format and control (anti-HLA-DQ, clone SPVL3) antibodies.
ORGANISM(S): Homo sapiens (Human) 
2024-03-30 | PXD048295 | Pride
Hla Tcr-like antibody Bispecific antibody Immunopeptidomics 
UnknownThe physiological interactome of TCR-like antibody therapeutics in human tissues.
Not available
S-EPMC11021511 | biostudies-literature
UnknownThe potential applications of T cell receptor (TCR)-like antibody in cervical cancer immunotherapy.
Not available
S-EPMC8381793 | biostudies-literature
UnknownTCR-like antibody drug conjugates mediate killing of tumor cells with low peptide/HLA targets.
Not available
S-EPMC5419083 | biostudies-literature
UnknownTargeting intracellular LMP2 with costimulatory signal-armed antibody-like TCR T cells.
Not available
S-EPMC12128957 | biostudies-literature
UnknownExamining variable domain orientations in antigen receptors gives insight into TCR-like antibody design.
Not available
S-EPMC4168974 | biostudies-literature
UnknownBinding of TCR multimers and a TCR-like antibody with distinct fine-specificities is dependent on the surface density of HLA complexes.
Not available
S-EPMC3519586 | biostudies-literature
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