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ProteomicsInvestigation of inter- and intra-day variability of tear fluid regarding flow rate, protein concentration as well as protein composition
Purpose: Determination of inter- and intra-day variations in tear flow rate, tear fluid protein concentration as well as protein composition regarding their impact for future biomarker studies.Methods: Tear fluid was collected non-invasively from 18 healthy subjects performing Schirmer tests at four...
ORGANISM(S): Homo sapiens (Human) 
2023-10-24 | PXD037811 | Pride
Mass spectrometry Tear fluid Schirmer test Tear flow rate  tear volume Protein concentration 
ProteomicsDog tear film proteome in-depth analysis
In this study, mass spectrometry was used to explore the canine tear proteome. Tear samples were obtained from six healthy dogs, and one-dimensional sodium dodecyl sulphate polyacrylamide gel electrophoresis (1D SDS-PAGE) was used as a first step to separate intact proteins into 17 bands. Each fract...
ORGANISM(S): Canis familiaris (Dog) (Canis lupus familiaris) 
2015-11-23 | PXD003124 | Pride
Sds-page Maldi Dog Tear fluid Proteome 
ProteomicsEffect of acupuncture on tear proteomics in patients with video display terminal-related dry eye
In our study, the tear proteome was compared with identify possible mechanisms and biomarkers for predicting acupuncture effectiveness in VDT-related dry eye. The results showed that the Ocular Surface Disease Index (OSDI) scores were significantly different between the acupuncture group (AC group) ...
ORGANISM(S): Homo Sapiens 
PXD051759 |
ProteomicsHuman tear (Diabetic macular edema), LC-MSMS
Tear proteome changes in diabetic macular edema with treatment. The constitution of tear protein change was assessed for difference in treatment response
ORGANISM(S): Homo sapiens (Human) 
2025-10-13 | PXD061821 | Pride
Lc-msms Diabetic macular edema Human tear 
ProteomicsAlterations in tear proteomes of adults with pre-diabetes and type 2 diabetes mellitus but without diabetic retinopathy
This study aims to explore the impact of type 2 diabetes mellitus (T2DM) on tear proteome, specifically investigating whether alterations occur before the development of diabetic retinopathy. Flush tear samples were collected from healthy subjects (n=13), subjects with preDM (n=16) and T2DM (n=18). ...
ORGANISM(S): Homo sapiens (Human) 
2025-08-04 | PXD062366 | Pride
Tear film  type 2 diabetes mellitus  mass spectrometry  proteomics Machine learning. 
ProteomicsAspergillus flavus Induced Alterations in Tear Protein Profile Reveal Pathogen-Induced Host Response to Fungal Infection
Aspergillus flavus and Fusarium sp. are primary causative agents of keratitis that results in corneal tissue damage leading to vision loss. The tear proteome of control and keratitis patients was profiled and compared. A total of 1873 proteins from control and 1400 proteins from patient tear were id...
ORGANISM(S): Homo sapiens (Human) 
2016-12-13 | PXD003825 | Pride
Mycotic keratitis  tear proteomics  complement  netosis  wound healing  glycosylation 
ProteomicsTear proteome of patients with non-infectious uveitis responders and non-responders to adalimumab
Proteomic anaysis of tear samples from patients with non-infectious uveitis responders and non-responders to adalimumab included in a cross-sectional study
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
MSV000095892 | MassIVE
ProteomicsHuman Tear using MALDI-TOF-MS for Dry Eye syndrome
Tears are a biological fluid that has diagnostic potential for ocular diseases. Extracellular vesicles (EVs), wildly detected in various biofluids including tears, are nanoparticles released by living cells and considered as promising detection sources for non-invasive liquid biopsy. Understanding t...
ORGANISM(S): Homo sapiens (Human) 
2020-08-20 | PXD020217 | Pride
Human Maldi-tof ms Tear Dry eye syndrome Extracellular vesicles 
ProteomicsHuman tear fluid proteome dataset for usage as a spectral library and for protein modeling
This article provides a detailed dataset of human tear fluid proteins. Samples were fractionated by sodium dodecyl sulfate (SDS) gel electrophoresis resulting in 48 fractions that were spiked with an indexed retention time (iRT) peptide standard. These data are based on a data-dependent acquisition ...
ORGANISM(S): Homo sapiens (Human) 
2019-08-15 | PXD011075 | Pride
Dia Protein modeling Tear fluid Spectral library Dda Lc-ms/ms 
ProteomicsPotential tear biomarkers for the early diagnosis of Parkinson's disease- A pilot study
Parkinson's disease (PD) is the second most common neurodegenerative disease after Alzheimer's disease. The purpose of this study was to analyze the profile of the tear proteome of patients with idiopathic PD (iPD), carriers of the E46K-SNCA mutation and healthy subjects (CT) and to identify biomark...
ORGANISM(S): Homo sapiens (Human) 
2022-02-14 | PXD028811 | Pride
Biomarkers  parkinson’s disease  tear film  lysosome 
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