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MetabolomicsMechanism of Organic Plant Protection Technology in Controlling Apple Bitter Pit: Insights from Integrated Transcriptomic and Metabolomic Analyses

Apple bitter pit (ABP), a severe physiological disorder, severely impairs the quality and yield of the susceptible 'Qingcui' apple. This study investigated the control efficacy and mechanism of a three-in-one Organic Plant Protection Technology (OPPT) against ABP, with treatments set as control (...

2026-02-26 | MTBLS13937 | MetaboLights
MetabolomicsMetabolic alterations in pea leaves during arbuscular mycorrhiza development

Arbuscular mycorrhiza (AM) is known to be a mutually beneficial plant-fungal symbiosis; however, the effect of mycorrhization is heavily dependent on multiple biotic and abiotic factors. Therefore, for the proper employment of such plant-fungal symbiotic systems in agriculture, a detailed underst...

2020-02-09 | MTBLS893 | MetaboLights
MetabolomicsMetabolomics guides rational development of a simplified cell culture medium for drug screening against Trypanosoma brucei
In vitro culture methods underpin many experimental approaches to biology and drug discovery. The modification of established cell culture methods to be more biologically relevant, or to optimise growth, is traditionally a laborious task. Emerging metabolomics technology enables rapid evaluation of ...
2015-05-14 | MTBLS49 | MetaboLights
MetabolomicsIntegrative multi-omics analysis of rumen development in early-life yaks
This study investigates the developmental changes in the rumen of early-life yaks using integrative metagenomics, metabolomics, histology, fermentation profiling, and single-cell transcriptomics. Rumen fluid and epithelial tissue samples collected from yaks at 1, 6, and 12 months of age were analyze...
2026-04-21 | MTBLS14340 | MetaboLights
MetabolomicsSingle-Cell and Spatial Multi-Omics Reveal Mechanical Stress Driving Heterogeneous Xylem Development in Populus [Spatial metabolomics_LCM]
Xylem, the predominant tissue for structural support, forms tension wood with G-layer-rich fibers under mechanical stress. Despite being recognized over a century ago, three key biological questions remained unclear: (1) Are fibers in normal and tension wood distinct cells due to morphological diffe...
2025-06-16 | MTBLS12561 | MetaboLights
MetabolomicsMulti-kingdom gut microbiota dysbiosis is associated with the development of pulmonary arterial hypertension

Gut microbiota dysbiosis has been implicated in pulmonary arterial hypertension (PAH). However, most studies have focused on the bacterial community and the exact role and mechanisms of multi-kingdom gut microbiota, including bacteria, archaea and fungi in PAH remains largely unclear. Idiopathic ...

2025-05-12 | MTBLS10563 | MetaboLights
MetabolomicsPolystyrene nanoparticles promote endometrial cancer development through the ACSS2-mediated reprogramming of arachidonic acid metabolism

Microplastics and nanoplastics are commonly found in our everyday environments. So far, microplastics and nanoplastics have been detected in various tissues and bodily fluids, including hair, sputum, digestive tissue, lungs, blood, and placental tissue. Although some studies indicate that micropl...

2026-02-05 | MTBLS13850 | MetaboLights
MetabolomicsEffects of Trichoderma and Salicylic Acid/Methyl Jasmonate on the Growth, Development, and Lipid Metabolism of Codonopsis pilosula

Endophytic fungi and phytohormone signaling can jointly influence growth–defense trade-offs in medicinal plants by reprogramming metabolism in a stage-dependent manner. To elucidate how the endophytic fungus Trichoderma longibrachiatum FG and exogenous salicylic acid (SA) and methyl jasmonat...

2026-03-24 | MTBLS14124 | MetaboLights
MetabolomicsIntegrated lipidomic and transcriptomic analysis uncovers the lipid dynamic changes in Camellia weiningensis during seed development

Oil-tea Camellia is a promising woody oil crop that has been widely used as a cooking oil, lubricant, and cosmetics. However, there is a lack of dominant varieties suitable for high-altitude cold mountainous regions. Camellia weiningensis (C. weiningensis) is the only h...

2026-01-27 | MTBLS13636 | MetaboLights
MetabolomicsIntegrated Metabolomics and Transcriptomics Analyses Reveal Anthocyanin and Carotenoid Biosynthesis Involved in Color Development in Willow Bark

Shrub willow has strong adaptability, large biomass and short rotation period. Colorful willow barks have great ornamental and economic value. To study the color regulation mechanism, metabolomics and transcriptomics were used to analyze the purple, green and red barks. In the positive mode, a to...

2022-08-10 | MTBLS4820 | MetaboLights
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