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TranscriptomicsWhole genome \"TraDIS-Xpress\" assay to determine gene roles during growth of E. coli in different concentrations of the antibiotics trimethoprim and sulfamethoxazole
To assay every gene in the E. coli genome to identify those that contribute to increased or decreased susceptibility to the antibiotics trimethoprim and sulfamethoxazole. This will help to define more accurately those bacterial cell mechanisms that contribute to these phenomena and provide informat...
ORGANISM(S): Escherichia coli str. K-12 substr. MG1655 
2020-10-19 | E-MTAB-9305 | biostudies-arrayexpress
GenomicsHigh resolution chemical-genomics identifies targets for synergistic antibiotics with aztreonam
A whole genome screen was used to assay every gene of Escherichia coli strain BW25113 to identify genes involved in susceptibility to the monobactam (beta-lactam) antibiotic aztreonam. The methodology has been called TraDIS-Xpress, and is a version of TraDIS or Tn-seq. A transposon mutant library c...
ORGANISM(S): Escherichia coli str. K-12 substr. MG1655 
2024-07-06 | E-MTAB-11576 | biostudies-arrayexpress
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