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MetabolomicsAntibiotics create a shift from mutualism to competition in human gut communities with a longer-lasting impact on fungi than bacteria

Background

Antibiotic treatment has a well-established detrimental effect on the gut bacterial composition, but effects on the fungal community are less clear. Bacteria in the lumen of the gastrointestinal tract may limit fungal colonization and invasion. Antibiotic drugs t...

2020-09-28 | MTBLS1846 | MetaboLights
MetabolomicsAssessment of human plasma and urine sample preparation for re-producible and high-throughput UHPLC-MS clinical metabolic phenotyping

Clinical metabolic phenotyping employs metabolomics and lipidomics to detect and measure thousands of metabolites and lipids within human samples. This approach aims to identify metabolite and lipid changes between phenotypes (e.g. disease status) that aid understanding of biochemical mechanisms ...

2020-08-06 | MTBLS1465 | MetaboLights
UnknownMolecular analysis of a laccase gene from the white rot fungus Pycnoporus cinnabarinus.
Not available
S-EPMC106228 | biostudies-literature
TranscriptomicsUranium extremophily is an adaptive, rather than intrinsic, feature for extremely thermoacidophilic Metallosphaera species
Thermoacidophilic archaea are found in heavy metal-rich environments and, in some cases, these microorganisms are causative agents of metal mobilization through cellular processes related to their bioenergetics. Given the nature of their habitats, these microorganisms must deal with the potentially ...
ORGANISM(S): Metallosphaera prunae 
2012-09-25 | E-GEOD-40796 | biostudies-arrayexpress
ProteomicsHyperosmolarity adversely impacts heterologous secretory protein synthesis by Yarrowia lipolytica
In this research we were interested in answering a question whether subjecting Y. lipolytica strain overproducing recombinant secretory protein (rs-Prot) to a specific, pre-optimized stress factor may enhance synthesis of the target macromolecule. Increased osmolarity (3 Osm/kg) was the primary stre...
ORGANISM(S): Yarrowia Lipolytica (ncbitaxon:4952) 
2021-10-13 | MSV000088228 | MassIVE
MetabolomicsIsotopomer analysis of MCF-7 breast cancer cell line incubated with 13C labelled glucose (GC-MS assay)
MS and NMR are two of the most powerful spectroscopic techniques used in the field of fluxomics, to analyze the flux distributions in cellular metabolomic pathways. Both of them possess pros and cons, such as, MS being the most sensitive and low-cost technique, while needs extensive sample processin...
2018-05-02 | MTBLS182 | MetaboLights
MetabolomicsThe effects of oligomycin administration and glutamine deprivation on metabolic profile of MCF7 breast cancer cell line measured using [1,2-13C2]-D-glucose and [U-13C5]-L-glutamine as tracers
This study aims to establish a comprehensive, genome-scale metabolic model (GSMM) combining different omics data of different regulatory levels of breast cancer cells in order to elucidate the way that these regulatory levels affect or determine each other. Together with transcriptomics, proteomics ...
2021-01-18 | MTBLS183 | MetaboLights
TranscriptomicsEverolimus
The effect of Everolimus (RAD001) on primary isolated human dermal microvascular endothelial (HDMVEC) and Fibroblast Cells as well as human glioblastoma brain tumor cell line (U87).
ORGANISM(S): Homo sapiens 
2013-11-12 | E-MEXP-3802 | biostudies-arrayexpress
TranscriptomicsU87_Radio_Resistance_Invasive_Noninvasive
Background: Glioblastoma multiforme (GBM) is the most common and malignant primary brain tumor in adults. Radiotherapy is together with surgery the mainstay treatment in management of patients with GBM, however, infiltrative growth pattern and radioresistance of glioma cells impedes therapeutic effe...
ORGANISM(S): Homo sapiens 
2023-11-08 | E-MTAB-4608 | biostudies-arrayexpress
UnknownHyperosmolarity adversely impacts recombinant protein synthesis by Yarrowia lipolytica-molecular background revealed by quantitative proteomics.
Not available
S-EPMC8720085 | biostudies-literature
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