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TranscriptomicsTenascin-C modifies expression levels and territories of key patterning genes during spinal cord astrocyte specification [mus musculus]
We demonstrate for the first time that the extracellular matrix glycoprotein Tenascin-C regulates the expression of key patterning genes during late embryonic spinal cord development, leading to a timely maturation of gliogenic neural precursor cells. We first show that Tenascin-C is expressed by gl...
ORGANISM(S): Mus musculus 
2011-10-19 | E-GEOD-33091 | biostudies-arrayexpress
TranscriptomicsMKL1-dependent tenascin-C transcription
The aim of the experiment is to investigate whether megakaryoblastic leukemia factor-1 (MKL1) induces tenascin-C in normal mammary epithelial HC11 and tumor mammary epithelial 4T1 cell lines, as well as to identify other genes that are transcriptionally regulated by MKL1. For this purpose, we compar...
ORGANISM(S): Mus musculus 
2011-06-10 | E-MEXP-3232 | biostudies-arrayexpress
TranscriptomicsTranscriptome of soleus muscle of Tenascin-C deficient 129/SV mice
1 year-old male Tenascin-C deficient 129/SV mice with the targeted insertion of a beta-lactamase cassette in the NcoI site of exon 2 of the TNC gene (Forsberg, E., Hirsch, E., Frohlich, L., Meyer, M., Ekblom, P., Aszodi, A., Werner, S. & Fassler, R. (1996) Proc. Natl. Acad. Sci U. S. A 93, 6594-6599...
ORGANISM(S): Mus musculus 
2010-06-25 | E-GEOD-8550 | biostudies-arrayexpress
TranscriptomicsTranscriptome of reloaded soleus muscle of Tenascin-C deficient 129/SV mice
1 year-old male Tenascin-C deficient 129/SV mice with the targeted insertion of a beta-lactamase cassette in the NcoI site of exon 2 of the TNC gene (Forsberg, E., Hirsch, E., Frohlich, L., Meyer, M., Ekblom, P., Aszodi, A., Werner, S. & Fassler, R. (1996) Proc. Natl. Acad. Sci U. S. A 93, 6594-6599...
ORGANISM(S): Mus musculus 
2010-06-25 | E-GEOD-8551 | biostudies-arrayexpress
TranscriptomicsComparison of tenascin-C proficient versus tenascin-C deficient Mouse Embryonic Fibroblasts (MEFs)
In order to investigate what signalling pathways are turned on by tenascin-C, we generated Mouse Embryonic Fibroblasts (MEFs) deficient for tenascin-C and compared their gene expression profile to MEFs proficient for tenascin-C. TNC-KO MEFs as well as WT MEFs in which tenascin-C was knocked-down (fo...
ORGANISM(S): Mus musculus 
2011-02-22 | E-GEOD-23547 | biostudies-arrayexpress
TranscriptomicsTenascin C prevents acute aortic dissection in mice
Acute aortic dissection (AAD) is one of the major aortic diseases that occurs without a preceding symptom and often results in sudden death. Despite the recent advances in cardiovascular medicine, AAD remains a serious problem because its molecular pathogenesis is largely unknown. In this paper, w...
ORGANISM(S): Mus musculus 
2015-03-27 | E-GEOD-36899 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mouse P7 and adult wt and Tenascin-R (Tnr) deficient mice brain
We used the microarray to investigate the lack of Tenascin-R in brain of adult and P7 mice. The aim was to find differential expressed genes which could explain the behaviour differences between the tenascin wt and ko mice. The data show that not many genes are dysregulated in the Tnr deficient mous...
ORGANISM(S): Mus musculus 
2009-12-19 | E-GEOD-19454 | biostudies-arrayexpress
TranscriptomicsmiRNA array for LPS-activated tnc+/+ and tnc-/- macrophages
Endogenous molecules generated upon pathogen invasion or tissue damage serve as danger signals that activate host defence, however their precise immunological role remains unclear. Tenascin-C is an extracellular matrix glycoprotein that is specifically induced upon injury and infection. We have show...
ORGANISM(S): Mus musculus 
2012-10-18 | E-GEOD-41584 | biostudies-arrayexpress
ProteomicsTenascin-C promotes tumor angiogenesis through pro-angiogenic and anti-angiogenic effects involving YAP, Ephrin-B2 and CXCL12 signaling
In the tumor microenvironment the extracellular matrix molecule tenascin-C is highly expressed which correlates with worsened survival prognosis. Tenascin-C promotes multiple steps in cancer progression. In particular, tenascin-C promotes the tumor angiogenic switch and the formation of more but poo...
ORGANISM(S): Homo sapiens (Human) Mus musculus (Mouse) 
2016-11-07 | PXD005217 | Pride
Tenascin 
ProteomicsAutophagy Deficiency Promotes Triple-Negative Breast Cancer Resistance to T Cell-Mediated Cytotoxicity by Blocking Tenascin-C Degradation
Most triple-negative breast cancer (TNBC) patients fail to respond to T cell-mediated immunotherapies. Unfortunately, the molecular determinants are still poorly understood. Breast cancer is the disease genetically linked to a deficiency in autophagy. Here, we show that autophagy promotes tumour imm...
ORGANISM(S): Mus musculus (Mouse) 
2020-08-05 | PXD019947 | Pride
Tnbc Tenascin-c T cell-mediated killing Autophagy deficiency Immune checkpoint inhibitors 
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