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TranscriptomicsHGPalmer-PDX-NVP-TNKS656
Strong activation of the oncogenic Wnt/beta-catenin pathway is a main mechanism of resistance to FOXO3a-induced apoptosis promoted by PI3K and AKT inhibitors in colorectal cancer (CRC). Reducing Wnt/beta-catenin activity would sensitize colorectal tumors to these inhibitors. However, no Wnt/beta-cat...
ORGANISM(S): Homo sapiens 
2015-08-10 | E-MTAB-2446 | biostudies-arrayexpress
TranscriptomicsMolecular Profiling of Chemoresistant Slow Cycling Cancer-Initiating Cells from human colorectal cancer, glioma and melanoma.
SUMMARY: Dormant or slow cycling tumour cells can form a residual chemoresistant reservoir responsible for relapse in patients, years after curative surgery and adjuvant therapy. Since their isolation from human tumors has been a long-stalled technical challenge preventing a direct study of their fu...
ORGANISM(S): Homo sapiens 
2018-06-28 | E-MTAB-4004 | biostudies-arrayexpress
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