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GenomicsPluripotency Factors Regulate Definitive Endoderm Specification through Eomesodermin
Understanding the molecular mechanisms controlling early cell fate decisions in mammals is a major objective towards the development of robust methods for the differentiation of human pluripotent stem cells into clinically relevant cell types. Here, we used human embryonic stem cells (hESCs) to stud...
ORGANISM(S): Homo sapiens 
2011-01-25 | E-GEOD-26097 | biostudies-arrayexpress
TranscriptomicsSynergism between Activin A and BMP4 in directing the formation of definitive endoderm in human embryonic stem cells
Human embryonic stem cells (HESCs) herald tremendous promise for the production of clinically useful cell types for the treatment of injury and disease. Numerous reports demonstrate their differentiation into definitive endoderm (DE) cells, the germ layer from which pancreatic β cells and hepatocyte...
ORGANISM(S): Homo sapiens 
2011-11-10 | E-GEOD-30630 | biostudies-arrayexpress
TranscriptomicsPDX1 Binding in human embryonic stem cell derived pancreatic progenitor cells [expression profiling]
PDX1 binds and regulates numerous genes involved in human pancreatic development but also binds hepatic genes Total RNA was extracted from day 0, day 10 and day17 of differentiated HES3 cells. Comparisons were made for day 10 and day 17 to day 0.
ORGANISM(S): Homo sapiens 
2014-06-21 | E-GEOD-58665 | biostudies-arrayexpress
MetabolomicsRibosomal mistranslation leads to silencing of the unfolded protein response and increased mitochondrial biogenesis

Translation fidelity is the limiting factor in the accuracy of gene expression. With an estimated frequency of 10-4, errors in mRNA decoding occur in a mostly stochastic manner. Little is known about the response of higher eukaryotes to chronic loss of ribosomal accuracy as per an increase in the...

2019-09-17 | MTBLS106 | MetaboLights
GenomicsPDX1 Binding in human embryonic stem cell derived pancreatic progenitor cells [ChIP-seq]
PDX1 binds and regulates numerous genes involved in human pancreatic development but also binds hepatic genes Examination of PDX1 regulated genes in pancreatic derived cell types
ORGANISM(S): Homo sapiens 
2014-06-21 | E-GEOD-58685 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human embryonic stems cells grown in chemically defined medium supplemented with Activen and FGF or FGF2 and SB431542 to identify genes controlled by Activin/Nodal signalling
Human Embryonic Stem Cells (hESC) grown in chemically defined medium (CDM) supplemented with Activin and FGF were compared to hESCs grown for 48 hours in CDM supplemented with FGF2 and SB431542, an inhibitor of Activin/Nodal signalling. The objective of this experiment was to discover the identity o...
ORGANISM(S): Homo sapiens 
2009-03-14 | E-MEXP-1741 | biostudies-arrayexpress
UnknownAssociation scan of 14,500 nonsynonymous SNPs in four diseases identifies autoimmunity variants.
Not available
S-EPMC2680141 | biostudies-literature
TranscriptomicsVallier 3day endoderm
Transcriptional profiling of H9 human embryonic stem cells differentiated towards early endoderm over 72 hours in chemically defined media.
ORGANISM(S): Homo sapiens 
2011-01-26 | E-MTAB-467 | biostudies-arrayexpress
ProteomicsDefective insulin receptor signaling in hPSCs skews pluripotency and negatively perturbs neural differentiation
Proteomics and phosphoproteomics analyses of two human pluripotent stem cell (hPSC) lines with stable insulin receptor knock down. 6-plex TMT-based strategy was applied to compare control versus insulin receptor (IR) knockdown (n=3 replicates for each condition) for each cell lines (CHB8 and H9). D...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2020-04-16 | MSV000085298 | MassIVE
ProteomicsLiver Steatosis and Mitochondrial Dysfunction in Spinal Muscular Atrophy is Survival Motor Neuron-Dependent and Hepatocyte-Intrinsic
Spinal Muscular Atrophy (SMA) is typically characterized as a motor neuron disease, but extra-neuronal phenotypes are present in almost every organ in severely affected patients and animal models. Extra-neuronal phenotypes were previously underappreciated as patients with severe SMA phenotypes usual...
ORGANISM(S): Homo Sapiens (human) 
2024-05-09 | PXD045401 | JPOST Repository
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