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ProteomicsImmunotherapeutic antibodies derived from human tumor tertiary lymphoid structures
We report that intratumoral Tertiary Lymphoid Structures (TLS) in human ovarian cancer contain highly oligoclonal B cells that produce IgA and IgG. Using a recombinant antibody cloned from the dominant sequence of an ovarian cancer TLS, we abrogated the growth of the autologous human tumor in vivo, ...
ORGANISM(S): Homo sapiens (Human) 
2026-06-12 | PXD036740 | Pride
Ovarian cancer Target identification Antibodies Tertiary lymphoid structures 
TranscriptomicsNovel Immunotherapy-Induced Tertiary Lymphoid Aggregates Accumulate as Intratumoral Nodal Structures of Immune Regulation in Pancreatic Cancer
Immunotherapy provides an alternative approach for cancer treatment. However, in-depth analyses of the effects of immunotherapy on the tumor microenvironment (TME) have not been conducted in non-melanoma tumors. Here we describe changes in the pancreatic ductal adenocarcinoma (PDAC) TME following i...
ORGANISM(S): Homo sapiens 
2014-08-05 | E-GEOD-52171 | biostudies-arrayexpress
GenomicsInfiltrating B cells and tertiary lymphoid structures in the TME
Infiltrating B cells and tertiary lymphoid structures in the TME
PRJNA780577 | ENA
GenomicsGut-Resident IL10+CX3CR1hi Macrophages Induce Tertiary Lymphoid Structures and IgA Response in Situ
Gut-Resident IL10+CX3CR1hi Macrophages Induce Tertiary Lymphoid Structures and IgA Response in Situ
PRJNA497440 | ENA
TranscriptomicsInfiltrating B cells and tertiary lymphoid structures in the TME
Single-cell profiling of infiltrating B cells and tertiary lymphoid structures in the TME of gastric adenocarcinomas
ORGANISM(S): Homo sapiens 
2021-11-22 | GSE188895 | GEO
GenomicsNociceptive innervation limits tertiary lymphoid structures to promote lung cancer
Nociceptive innervation limits tertiary lymphoid structures to promote lung cancer
PRJNA1290269 | ENA
GenomicsLoss of Vascular Endothelial Notch Signaling Induces Tertiary Lymphoid Structures in the Kidney
Loss of Vascular Endothelial Notch Signaling Induces Tertiary Lymphoid Structures in the Kidney
PRJNA796573 | ENA
GenomicsLate-stage tertiary lymphoid structures in hepatocellular carcinoma treated with neoadjuvant immune checkpoint blockade [scRNA-seq]
Late-stage tertiary lymphoid structures in hepatocellular carcinoma treated with neoadjuvant immune checkpoint blockade [scRNA-seq]
PRJNA1136494 | ENA
GenomicsLate-stage tertiary lymphoid structures in hepatocellular carcinoma treated with neoadjuvant immune checkpoint blockade [bulk RNA-seq]
Late-stage tertiary lymphoid structures in hepatocellular carcinoma treated with neoadjuvant immune checkpoint blockade [bulk RNA-seq]
PRJNA1136492 | ENA
TranscriptomicsMolecular and spatial analysis unveils the functional basis of tertiary lymphoid structures in Sjogren’s syndrome[scRNA-seq]
The key role of tertiary lymphoid structures in autoimmune and non-autoimmune conditions has been recently appreciated. While many of the molecular mechanisms involved in tertiary lymphoid structure formation have been identified, their cellular sources and temporal and spatial relationship remain u...
ORGANISM(S): Homo sapiens 
2024-07-17 | GSE272409 | GEO
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