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ProteomicsInactivation of p21-Activated Kinase 2 (Pak2) Inhibits the Development of Nf2-Deficient Tumors by Restricting Downstream Hedgehog and Wnt Signaling
Since loss of the NF2 tumor suppressor gene results in p21-activated kinase (Pak) activation, PAK inhibitors hold promise for the treatment of NF2-deficient tumors. To test this possibility, we asked if loss of Pak2, a highly expressed group I PAK member, affects the development of malignant mesothe...
ORGANISM(S): Mus musculus (Mouse) 
2023-03-10 | PXD030571 | Pride
Conditional knockout mice  malignant mesothelioma  nf2 and cdkn2a tumor suppressor genes  pak  hedgehog and wnt signaling  cancer stem cells 
UnknownSeed Morphology of Allium L. (Amaryllidaceae) from Central Asian Countries and Its Taxonomic Implications.
Not available
S-EPMC7570352 | biostudies-literature
UnknownImpact of a Home-Based Remote Patient Monitoring System on Hospitalizations and Emergency Department Visits of Older Adults With Polypathology: Multicenter Retrospective Observational Study.
Not available
S-EPMC12461160 | biostudies-literature
UnknownBrain functional connectivity in sleep-related hypermotor epilepsy.
Not available
S-EPMC5842749 | biostudies-literature
UnknownRemote Patient Monitoring System for Polypathological Older Adults at High Risk for Hospitalization: Retrospective Cohort Study.
Not available
S-EPMC12279313 | biostudies-literature
UnknownRemote monitoring system for older adults at risk for complications: a scoping review.
Not available
S-EPMC12512857 | biostudies-literature
TranscriptomicsGenomeTiling
Samples were purchased from Clontech as mRNA. Hybridization material was generated through a random-priming amplification procedure (RP-AMP) using primers with a random sequence at the 3' end and a fixed motif at the 5' end. shDNP256 (first strand synthesis): 5'- TAG ATG CTG TTG NNN NNN NNN -3' sh...
ORGANISM(S): Homo sapiens 
2004-03-03 | E-GEOD-1097 | biostudies-arrayexpress
UnknownIsocitrate Dehydrogenase Mutations in Myelodysplastic Syndromes and in Acute Myeloid Leukemias.
Not available
S-EPMC7564409 | biostudies-literature
UnknownBreast Cancer: A Molecularly Heterogenous Disease Needing Subtype-Specific Treatments.
Not available
S-EPMC7151639 | biostudies-literature
UnknownTargeting histone methyltransferase and demethylase in acute myeloid leukemia therapy.
Not available
S-EPMC5749389 | biostudies-literature
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