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TranscriptomicsCynomolgus monkey testicular cDNAs for discovery of novel human genes
BACKGROUND: In order to contribute to the establishment of a complete map of transcribed regions of the human genome, we constructed a testicular cDNA library for the cynomolgus monkey, and attempted to find novel transcripts for identification of their human homologues. RESULT: The full-insert sequ...
ORGANISM(S): Homo sapiens 
2010-06-05 | E-GEOD-513 | biostudies-arrayexpress
ProteomicsHuman testicular matrix
ITo derive a scaffold from human testis for the purpose of tissue engineering and regenerative medicine, we developed a method to produce a cytocompatible decellularized testicular matrix (DTM) while maintaining the native tissue-specific characteristics and components. The potential benefits of tis...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2016-03-14 | MSV000079582 | MassIVE
TranscriptomicsTesticular lumicrine factors regulate ERK, STAT and NFKB pathways in the initial segment of the rat epididymis to prevent apoptosis
The initial segment of the epididymis is vital for male fertility, therefore, it is important to understand the mechanisms that regulate this important region. Deprival of testicular luminal fluid factors/lumicrine factors from epididymis, a subset of cells within the initial segment undergo apoptos...
ORGANISM(S): Rattus norvegicus 
2011-03-11 | E-GEOD-21806 | biostudies-arrayexpress
TranscriptomicsA molecular and phenotypic integrative approach to identify a no effect dose level for anti-androgen induced testicular toxicity
With the advent of high information content technologies, especially microarrays, it is pertinent to determine the impact of molecular data on the NOAELs. Consequently, we conducted an integrative study to identify a no transcriptomic effect dose using microarray analyses coupled with qPCR and deter...
ORGANISM(S): Rattus norvegicus 
2011-03-29 | E-GEOD-28202 | biostudies-arrayexpress
ProteomicsHuman testicular matrix - Derivation and characterization of a cytocompatible scaffold from human testis
ITo derive a scaffold from human testis for the purpose of tissue engineering and regenerative medicine, we developed a method to produce a cytocompatible decellularized testicular matrix (DTM) while maintaining the native tissue-specific characteristics and components. The potential benefits of tis...
ORGANISM(S): Homo sapiens (Human) 
2015-01-30 | PXD001524 | Pride
Testicular structure Extracellular matrix 3d cell culture 
TranscriptomicsPurification and transcriptomic analysis of mouse fetal Leydig cells reveals candidate genes for disorders of sex development
To examine the transcriptome of early testicular somatic cells during gonadogenesis at 12.5dpc RNA sequencing (RNA-Seq) was performed on murine primary testicular cell lineages isolated from the Sf1-eGFP line by FACS. The three main somatic cell lineages of the testis were isolated: the Sertoli cell...
ORGANISM(S): Mus musculus 
2015-05-21 | E-GEOD-65498 | biostudies-arrayexpress
TranscriptomicsmRNA expression of cancer and matched adjacent tissues of 7 testicular germ cell tumors and 10 transitional cell carcinomas of bladder
Genome-wide gene expression profile using deep sequencing technologies can drive the discovery of cancer biomarkers and therapeutic targets. Such efforts are often limited to profiling the expression signature of either mRNA or microRNA (miRNA) in a single type of cancer.Here we provided an integrat...
ORGANISM(S): Homo sapiens 
2013-09-01 | E-GEOD-31614 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human testis samples from men with highly defined and homogenous testicular pathologies reveals patterns that correlate with distinct stages of spermatogenesis
Identification of gene expression patterns that correlate with distinct stages of male germ cell development using biopsies from men with highly defined and homogenous testicular pathologies based on the Johnsen score procedure. The Johnsen score procedure is a classical histopathological scoring pr...
ORGANISM(S): Homo sapiens 
2008-06-11 | E-TABM-234 | biostudies-arrayexpress
TranscriptomicsMeiotic Consequences of Genetic Extension of Unsynapsed Autosomal Chromatin
We investigated the influence of extension of autosomal asynapsis on expression profiles during spermatogenesis. We used the mouse autosomal translocation T(16;17)43H (abbreviated T43H) and t12 haplotype, a natural variant of Chr 17 encompassing four adjacent non-overlapping inversions proximal to t...
ORGANISM(S): Mus musculus 
2014-05-09 | E-GEOD-29177 | biostudies-arrayexpress
GenomicsRRBS of human fetal testis treated to a mixture of DEHP/BPA
Fetal human fetal testes (8-11 weeks post-fertilization [WPF]) were cut into small pieces (~1 mm3 ) and 4-6 pieces/testis (depending of the age or size of the gonad) were insert into the muscle of the left back of two twin female mice. One week after surgery, one mouse was exposed by drinking water ...
ORGANISM(S): Homo sapiens 
2026-01-01 | E-MTAB-13840 | biostudies-arrayexpress
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